CS12 Exploration of an objective measure of cognitive fatigability in multiple sclerosis using the MSReactor digital platform

Sarossy Alexander; Gresle Melissa; Chao Zhu; Foong Yi Chao; Jeannette Lechner-Scott; Michael Barnett; Thomas Kalincik; Bruce Taylor; Katherine Buzzard; Nevin John; Allan Kermode; David Darby; Butzkueven Helmut; Walt Van Der; Daniel Merlo

doi:10.1136/bmjno-2025-ANZAN.20

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CS12 Exploration of an objective measure of cognitive fatigability in multiple sclerosis using the MSReactor digital platform

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CS12 Exploration of an objective measure of cognitive fatigability in multiple sclerosis using the MSReactor digital platform

Sarossy Alexander, Gresle Melissa, Chao Zhu, Foong Yi Chao, Jeannette Lechner-Scott, Michael Barnett, Thomas Kalincik, Bruce Taylor, Katherine Buzzard, Nevin John, …

BMJ neurology open, Vol.7(Suppl 1), pp.A8-A8

2025

DOI: https://doi.org/10.1136/bmjno-2025-ANZAN.20

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Abstract

Background/Objective Cognitive fatigability (CF) affects many with Multiple Sclerosis (MS), yet measurement remains challenging due to poor correlation with subjective fatigue reports. MSReactor cognitive screening platform offers potential for objective CF assessment, particularly for longitudinal monitoring in clinical settings. Objective To determine whether changes in error rates during sustained cognitive testing provide a platform for studies investigating CF and its relationship to disease progression. Methods Adults with relapsing-remitting and secondary-progressive MS were recruited from seven Australian tertiary MS clinics. Participants completed MSReactor cognitive testing battery: a simple reaction time, a choice reaction time, and a One back test (OBK, which is a measure of working memory). Each test required participants to make 32–35 responses to stimuli appearing on screen. CF was quantified as a sustained doubling of incorrect responses in the last third compared to first third of OBK test. Expanded Disability Status Scale (EDSS) was assessed as part of standard care. Results Among 836 participants, 113 (13.5%) demonstrated a sustained doubling of errors in OBK task over follow-up period (median 890 days, IQR: 1070). Of these, 7 participants with sustained increases in intra-test error rates subsequently had a 6-month confirmed disability progression event. Conclusion This study explores MSReactor as an objective measure of CF in MS. We identified a group of participants who consistently made more errors in latter third of a sustained working memory test, which appeared independent of future disability progression. Further research is needed to validate this finding against clinical correlates and work productivity.

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Title: CS12 Exploration of an objective measure of cognitive fatigability in multiple sclerosis using the MSReactor digital platform
Authors/Creators: Sarossy Alexander
Gresle Melissa
Chao Zhu - Monash University
Foong Yi Chao
Jeannette Lechner-Scott - Hunter New England Local Health District
Michael Barnett - Cooperative Trials Group for Neuro-Oncology
Thomas Kalincik
Bruce Taylor - Royal Hobart Hospital
Katherine Buzzard - Eastern Health
Nevin John - Monash University
Allan Kermode - Perron Institute for Neurological and Translational Science
David Darby - Alfred Health
Butzkueven Helmut
Walt Van Der
Daniel Merlo - Monash University
Publication Details: BMJ neurology open, Vol.7(Suppl 1), pp.A8-A8
Publisher: BMJ Publishing Group LTD
Identifiers: 991005828071207891
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Abstract

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