Causal involvement of DLPFC during bimanual coordination in older adults – an rTMS study

Stefanie Verstraelen; Koen Cuypers; Siel Depestele; Kim Van Dun; Julie Duque; Hakuei Fujiyama; Oron Levin; Stephan Swinnen; Raf Meesen

doi:10.3389/conf.fnins.2019.96.00047

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Causal involvement of DLPFC during bimanual coordination in older adults – an rTMS study

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Causal involvement of DLPFC during bimanual coordination in older adults – an rTMS study

Stefanie Verstraelen, Koen Cuypers, Siel Depestele, Kim Van Dun, Julie Duque, Hakuei Fujiyama, Oron Levin, Stephan Swinnen and Raf Meesen

Frontiers in Neuroscience, Vol.13

13th National Congress of the Belgian Society for Neuroscience (Brussels, Belgium, 24/05/2019)

2019

DOI: https://doi.org/10.3389/conf.fnins.2019.96.00047

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Abstract

Aging

bimanual coordination

dorsolateral prefrontal cortex (DLPFC)

Interhemispheric interaction

repetitive transcranial magnetic stimulation (rTMS)

The role of the dorsolateral prefrontal cortex (DLPFC) in the regulation of bimanual coordination appears to become crucial with aging. Age-related changes in the involvement of the DLPFC in bimanual coordination were studied by using disruptive repetitive TMS (rTMS), inducing a transient lesion in this brain structure. Neurophysiological as well as behavioral effects of suppressing DLPFC during the preparation and execution of a bimanual task were studied in 41 healthy adults (young and old). Specifically, we combined short-train rTMS with single pulse TMS to examine the effect of DLPFC suppression on the interhemispheric projection to the contralateral primary motor cortex (M1) during motor preparation. Findings revealed that compromised interhemispheric DLPFC-M1 disinhibition during motor preparation in older adults resulted in less accurate bimanual performance. The altered DLPFC-M1 interaction in older adults appeared to result from a decline in local inhibitory mechanisms in the DLPFC. In addition, the induction of DLPFC suppression affected task accuracy, but not movement stability in both age groups. Taken together, these results suggest that DLPFC acts as a key regulator in the control of bimanual movement coordination.

Details

Title: Causal involvement of DLPFC during bimanual coordination in older adults – an rTMS study
Authors/Creators: Stefanie Verstraelen
Koen Cuypers
Siel Depestele
Kim Van Dun
Julie Duque
Hakuei Fujiyama
Oron Levin
Stephan Swinnen
Raf Meesen
Publication Details: Frontiers in Neuroscience, Vol.13
Conference: 13th National Congress of the Belgian Society for Neuroscience (Brussels, Belgium, 24/05/2019)
Publisher: Frontiers Media SA
Identifiers: 991005616568707891
Copyright: © The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated
Murdoch Affiliation: Centre for Healthy Ageing
Language: English
Resource Type: Abstract

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