Book
Untranslated gene regions and other Non-coding elements: Regulation of eukaryotic gene expression
Untranslated Gene Regions and Other Non-coding Elements
Springer
2013
Abstract
There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as “junk DNA”, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5’ and 3’ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.
Details
- Title
- Untranslated gene regions and other Non-coding elements: Regulation of eukaryotic gene expression
- Authors/Creators
- L.W. Barrett (Author/Creator)S. Fletcher (Author/Creator)S.D. Wilton (Author/Creator)
- Publication Details
- Untranslated Gene Regions and Other Non-coding Elements
- Publisher
- Springer; Dordrecht, NL
- Identifiers
- 978-3-0348-0678-7; 991005543044907891
- Copyright
- 2013 The Authors
- Murdoch Affiliation
- Centre for Comparative Genomics
- Language
- English
- Resource Type
- Book
- Note
- Series Title: SpringerBriefs in Biochemistry and Molecular Biology; ISSN: 2211-9353
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