Book chapter
Animal models for the study of infection-associated preterm birth
Animal Models for the Study of Human Disease, pp.863-888
Academic Press Inc
2013
Abstract
In industrialized and developing countries, preterm birth (live delivery before 39 weeks of gestation) is both a leading cause of neonatal death and a major risk factor for respiratory, neurological, and cognitive disabilities in those infants who survive to adolescence. Intrauterine infection is considered a leading cause of preterm birth; data from clinical and experimental studies suggest that in utero infection accounts for upward of 40% of preterm deliveries.
This chapter is written with two aims: the first is to provide the reader with an introduction to infection-associated preterm birth, highlighting the importance of animal-based studies in the development of this field; and the second, adopting a practical focus, is designed to provide the reader with technical insight into the use of sheep as a model organism for the study of fetal inflammatory responses to the presence of microbial agonist in the uterine sphere.
Details
- Title
- Animal models for the study of infection-associated preterm birth
- Authors/Creators
- M.W. Kemp (Author/Creator) - The University of Western AustraliaG.C. Musk (Author/Creator) - Murdoch UniversityM. Saito (Author/Creator) - Tohoku University
- Contributors
- M. Conn (Editor)
- Publication Details
- Animal Models for the Study of Human Disease, pp.863-888
- Publisher
- Academic Press Inc; London, UK
- Identifiers
- 991005543662307891
- Copyright
- © 2013 Elsevier Inc.
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Book chapter
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