Abstract
Garenoxacin is a des-fluoro(6) quinolone that, as such, lacks a fluorine at the C-6 position in comparison with other fluoroquinolones such as ciprofloxacin, moxifloxacin, and levofloxacin, and has a difluoromethoxy substitution at position C-8 (Fung-Tomc et al., 2000). The molecular formula is 1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-(1-methyl-2, 3-dihydro-1H-5-isoindolyl)-4-oxo-1, 4-dihydro-3-quinoline-carboxylic acid methanesulfonate monohydrate (Takahata et al., 1999) (see Figure 114.1). Figure 114.1 Chemical structure of garenoxacin.