Book chapter
Metal-based antimalarial agents
Ligand Design in Medicinal Inorganic Chemistry, pp.205-225
John Wiley & Sons Inc
2014
Abstract
The present chapter will describe the efforts made to discover novel metal-based antimalarial agents using ligand design to improve efficacy. Malaria is still one of the most devastating human parasitic infections; the search for new antimalarial drugs is a high priority, as the parasites that cause the disease have developed a high resistance to many of the drugs currently available for treatment. Consequently, the development of new chemotherapeutic agents more effective against malaria and less toxic to the host is urgent. Such efforts have to be accompanied by research on the biochemistry of the parasite, in order to identify possible targets of action for the rational design of better drugs, taking in account the importance of both the metal and the ligand to the overall potency.
Details
- Title
- Metal-based antimalarial agents
- Authors/Creators
- M. Navarro (Author/Creator) - Murdoch UniversityC. Biot (Author/Creator) - Unité de Glycobiologie Structurale et Fonctionnelle
- Contributors
- T. Storr (Editor)
- Publication Details
- Ligand Design in Medicinal Inorganic Chemistry, pp.205-225
- Publisher
- John Wiley & Sons Inc; Chichester, UK
- Identifiers
- 991005543894807891
- Copyright
- © 2014 John Wiley & Sons, Ltd.
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Book chapter
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