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Review
Understanding the Mechanisms Driving Fibrosis Following Cochlear Implantation—Lessons from Other Tissues
Cells, Vol.14(23), 1924
2025
Abstract
Cochlear implants are highly successful in restoring speech perception but variability in outcomes exists. Post-surgical fibrosis and neo-ossification are thought to play a significant role, being linked to increased impedance and loss of residual hearing and posing challenges for re-implantation. Hence, there is growing interest in pharmacological interventions to limit intracochlear fibrosis and neo-ossification. While current approaches focus on steroids, studies in other organs have identified many candidate drugs. However, selection is hindered by a limited understanding of the molecular and cellular mechanisms driving fibrosis after implantation. This review introduces potential drug candidates for cochlear implant-induced fibrosis, with many targeting core fibrotic pathways such as TGF-β/SMAD, PDGF, and Wnt/β-catenin or inhibiting pro-inflammatory signalling. By drawing on lessons from other tissues, this review identifies mechanisms and therapeutic approaches adaptable to the cochlea. Understanding fibrosis across organs will guide strategies to prevent or reverse cochlear fibrosis. Their translation requires careful evaluation of local delivery, minimal ototoxicity, and effects on the electrode–tissue interface.
Details
- Title
- Understanding the Mechanisms Driving Fibrosis Following Cochlear Implantation—Lessons from Other Tissues
- Publication Details
- Cells, Vol.14(23), 1924
- Publisher
- MDPI
- Number of pages
- 24
- Identifiers
- 991005838966307891
- Copyright
- © 2025 by the authors.
- Murdoch Affiliation
- School of Medical, Molecular and Forensic Sciences
- Resource Type
- Review
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Source: InCites
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- Collaboration types
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- Citation topics
- 1 Clinical & Life Sciences
- 1.150 Hearing Loss
- 1.150.427 Hearing Technologies
- Web Of Science research areas
- Cell Biology
- ESI research areas
- Biology & Biochemistry