Conference presentation
Epstein-Barr virus (EBV) - specific antibodies in multiple sclerosis patients, including targeted investigation of a candidate EBV nuclear antigen-1 (EBNA-1) B cell epitope
28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (Lyon, France, 10/10/2012–13/10/2012)
2012
Abstract
Multiple Sclerosis (MS) is a very complex disease, with different genetic and environmental factors contributing to its risk. In particular, infection with Epstein-Barr Virus (EBV) has been shown to increase MS risk. This risk is moderately associated with anti-viral capsid antigen (VCA) antibodies, but very strongly associated for anti-EBV nuclear antigen-1 (EBNA-1) antibodies. Focus on EBNA-1 has uncovered that antibody reactivity against a C-terminal part the of the protein (amino acid (aa) positions 385-420) is a stronger risk marker than antibodies against the whole EBNA-1 protein. Recently, in a small study in twins (n=12), a putative B cell epitope within this region (aa 401-411) has been identified as a target for antibodies that are specifically enriched in MS patients compared with healthy controls.
Details
- Title
- Epstein-Barr virus (EBV) - specific antibodies in multiple sclerosis patients, including targeted investigation of a candidate EBV nuclear antigen-1 (EBNA-1) B cell epitope
- Authors/Creators
- K. Strautins (Author/Creator)M. Tschochner (Author/Creator)I. James (Author/Creator)C.M. Berry (Author/Creator)D. Nolan (Author/Creator)
- Conference
- 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (Lyon, France, 10/10/2012–13/10/2012)
- Identifiers
- 991005540875907891
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences; Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Conference presentation
Metrics
51 File views/ downloads
104 Record Views