Potential for paralogous mapping to simplify the genetics of diseases and functions associated with MHC haplotypes

Roger Dawkins; Jemma Berry; Patricia Martinez; Silvana Gaudieri; Jennie Hui; Sonia Cattley; Natalie Longman; Jerzy Kulski; Patrick Carnegie

doi:10.1007/978-4-431-65868-9_10

Conference proceeding

Potential for paralogous mapping to simplify the genetics of diseases and functions associated with MHC haplotypes

Roger Dawkins, Jemma Berry, Patricia Martinez, Silvana Gaudieri, Jennie Hui, Sonia Cattley, Natalie Longman, Jerzy Kulski and Patrick Carnegie

Major Histocompatibility Complex: Evolution, Structure, and Function, pp.146-157

6th International Workshop on MHC Evolution (Hayama, Japan, 25/05/1999–29/05/1999)

2000

DOI: https://doi.org/10.1007/978-4-431-65868-9_10

Abstract

Haemochromatosis and autoimmunity

Immunoregulation

Major histocompatibility complex

Psoriasis

The major histocompatibility complex (MHC) region contains several hundred genes in addition to the well-known HLA Class I and II loci. Some of these will explain MHC-disease associations. We have used paralogous and syntenic mapping to short list candidates and conclude that non-HLA genes present on human 6,1 and 19 and murine 17, 4 and 7 regulate immune responses and autoimmune disease. These genes are likely to be components of the early pre-HLA MHC and include tenascin and possibly notch inter alia.

Details

Title: Potential for paralogous mapping to simplify the genetics of diseases and functions associated with MHC haplotypes
Authors/Creators: Roger Dawkins - The University of Western Australia
Jemma Berry - The University of Western Australia
Patricia Martinez - The University of Western Australia
Silvana Gaudieri - The University of Western Australia
Jennie Hui - The University of Western Australia
Sonia Cattley - The University of Western Australia
Natalie Longman - The University of Western Australia
Jerzy Kulski - The University of Western Australia
Patrick Carnegie - The University of Western Australia
Contributors: Masanori Kasahara (Editor)
Publication Details: Major Histocompatibility Complex: Evolution, Structure, and Function, pp.146-157
Conference: 6th International Workshop on MHC Evolution (Hayama, Japan, 25/05/1999–29/05/1999)
Publisher: Springer Tokyo; Tokyo
Identifiers: 991005624463007891
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Conference proceeding

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