Thesis
A Meta-Analysis to Validate the Analysis of Anticoagulant Medications in Biological Samples
Masters by Research, Murdoch University
2023
Abstract
Anticoagulants are an essential class of medication used to prevent or minimise coagulation. These medications work primarily by interfering with the clotting cascade, completely stopping or reducing the rate of clot formation. As with all medicines, there is a need to ensure that the prescribed dosage results in the desired therapeutic outcome. As such, adequate and precise monitoring is necessitated. These processes follow comprehensive knowledge of the types of anticoagulants and their pharmacokinetic and pharmacodynamic properties. Additionally, the analytical technique chosen when monitoring anticoagulant dosage must be sensitive and specific enough to ensure accurate measurements. This paper discusses two types of anticoagulants: parenteral and oral. Additionally, an overview of the global trends in their consumption is discussed herein. The article discusses current analytical techniques for anticoagulant analysis, which include immunoassays, chromatographic methods, coagulation assays, mass spectrometry and electrophoresis. LC-MS is then identified as a viable analytical technique for analysing anticoagulants in biological samples. A discussion of the critical parameters and instrumentation of this technique follows.
Details
- Title
- A Meta-Analysis to Validate the Analysis of Anticoagulant Medications in Biological Samples
- Authors/Creators
- Ken K Mwangi
- Contributors
- John Coumbaros (Supervisor) - Murdoch University, School of Medical, Molecular and Forensic Sciences
- Awarding Institution
- Murdoch University; Masters by Research
- Identifiers
- 991005624668907891
- Murdoch Affiliation
- School of Medical, Molecular and Forensic Sciences
- Resource Type
- Thesis
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