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Derivatisation of chemical warfare agent degradant without removal of water
Thesis   Open access

Derivatisation of chemical warfare agent degradant without removal of water

Xiang Le Chua
Masters by Coursework, Murdoch University
2018
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Abstract

Degradation products are distinct chemical signature for the detection of chemical warfare agents and forensic attribution in cases where the parent compound no longer exists. Being the common degradant to nerve agents, methylphosphonic acid serves as an explicit biomarker for the use of nerve agents. However, this non-volatile compound requires derivatisation prior to its detection, which incurs time-limiting factor and error. Therefore, development for a novel rapid and simple approach for identifying these degradants is of high importance to shed light on the use of chemical warfare agents and remediation of impacts. With the success of a recent pilot study for derivatisation of methylphosphonic acid without elimination of water, a subsequent quantitative study can be proceeded to assess on its practicality and efficiency.

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