Thesis
Designing and optimising splice modulating antisense oligonucleotides that redirect pre-mRNA processing of apolipoprotein C-III
Honours, Murdoch University
2023
Abstract
Cardiovascular disease (CVD) is the leading cause of global deaths and remains a worldwide public health concern (1, 2). The World Health Organisation estimates that CVD is responsible for 17.9 million deaths each year, with approximately 85% of these deaths attributed to heart attack or stroke (2). One of the primary contributors is atherosclerotic cardiovascular disease (ASCVD) which is a progressive disease characterised by the accumulation of lipids and other particles in the large arteries (1, 2). This can lead to the formation of plaques that can calcify and rupture, disrupting blood flow and potentially causing myocardial infarction or stroke (1). The enormous strain placed on the health care system due to CVD has fuelled the development of novel therapeutics which utilise unexplored strategies to help ease the burden on the healthcare system and allow for valuable resources to be redirected to other areas of need...
Details
- Title
- Designing and optimising splice modulating antisense oligonucleotides that redirect pre-mRNA processing of apolipoprotein C-III
- Authors/Creators
- Kara B Farstad-O'Halloran
- Contributors
- May Aung-Htut (Supervisor) - Murdoch University, Centre for Molecular Medicine and Innovative TherapeuticsCraig McIntosh (Supervisor) - Murdoch University, Centre for Molecular Medicine and Innovative Therapeutics
- Awarding Institution
- Murdoch University; Honours
- Identifiers
- 991005602256607891
- Murdoch Affiliation
- Centre for Molecular Medicine and Innovative Therapeutics; College of Environmental and Life Sciences
- Resource Type
- Thesis
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