Thesis
Intra-operative comparison of portal vein pressure pre- and post- partial hepatectomy or complete splenectomy in the dog
Masters by Research, Murdoch University
2023
Abstract
Background: Partial hepatectomy and complete splenectomy are performed in dogs for treatment of pathology. The spleen is a contributor to portal vein flow and the liver is a recipient of flow. The consequence of liver and splenic resections on portal vein pressure (PVP) in dogs, with implications to ongoing liver function, are unknown. In people and animal models, increased PVP after major hepatectomy and decreased PVP after splenectomy, is well-documented.
Objective: To compare intra-operative PVP pre- and post-hepatectomy or splenectomy in dogs.
Study Design: 1. Case report 2. Prospective quasi interventional clinical study
Animals: Client-owned dogs presented for therapeutic hepatectomy or splenectomy
Methods: 1. A case report of progressive hepatopathy post central division hepatectomy. 2. Dogs undergoing therapeutic hepatectomy or splenectomy . A jejunal mesenteric venous catheter was connected to a pressure transducer for direct measurement of PVP. The PVP (mmHg) was continuously displayed and video recorded for later analysis. Portal vein pressure pre- and post-resection were compared and described as either elevation (+) or reduction (-) .
Results: 1. A progressive hepatopathy in a 10-year-old female Lhasa Apso dog documented by sequential serum biochemistry, computed tomography and liver biopsy findings was discussed with specific reference to comparable PHLF criteria in people. 2. Four of six dogs undergoing hepatectomy had an immediate elevation in PVP (P=0.2343). Twelve of fifteen dogs undergoing splenectomy had an immediate reduction in PVP (P=0.014).
Conclusion: 1. The case report documents microscopic changes consistent with elevation in PVP post-hepatectomy. These changes, in conjunction with other clinical criteria displayed by the case, prompt consideration for PHLF development in the dog. 2. The results of the exploratory investigation demonstrated immediate elevation, and immediate reduction, in PVP following hepatectomy and splenectomy, respectively. This gives early insight into portal venous dynamics after liver and splenic resection.
Details
- Title
- Intra-operative comparison of portal vein pressure pre- and post- partial hepatectomy or complete splenectomy in the dog
- Authors/Creators
- Sean Wood
- Contributors
- Giselle Hosgood (Supervisor) - Murdoch University, School of Veterinary MedicineAnthea Raisis (Supervisor)Carla Appelgrein (Supervisor)
- Awarding Institution
- Murdoch University; Masters by Research
- Identifiers
- 991005617463007891
- Murdoch Affiliation
- School of Veterinary Medicine
- Resource Type
- Thesis
- Note
- Research Masters with Training (RMT) of Murdoch University
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