Thesis
Reducing risk factors in individuals at-risk of type 2 diabetes: Combining early-time restricted feeding and multimodal exercise
Masters by Research, Murdoch University
2023
Abstract
Background: Type 2 diabetes (T2D) is a global health priority, with worldwide prevalence and economic burden projections reaching 7.1% of adults and 2.2 trillion USD respectively by 2030. Preventative, non-invasive strategies such as lifestyle interventions (exercise and diet combination) are important foundations for T2D management and prevention. Early time-restricted feeding (eTRF, ≤12-hour feeding window, ≥5-hour fast before bed) has recently shown improvements in body weight, fat mass, and several metabolic parameters.
Purpose: Individually, exercise and eTRF can reduce T2D risk factors. Combining exercise and eTRF as an effective treatment which may reduce T2D risk has not occurred. Therefore, this study aims to determine whether an intensive 2-week intervention of eTRF and multimodal exercise will improve total body weight and fat mass to a greater degree than eTRF alone, in individuals identified as being at-risk of developing T2D
.
Methods: This study adopted a two-week RCT design with 22 non-T2D overweight/obese (BMI ≥27) participants (≥18yrs). A two-week control period was performed before the trial to obtain baseline data, including dietary habits, exercise patterns and circadian rhythm. Primary outcomes were modifications in body anthropometrics (body weight, lean mass, and fat mass), dual-energy x-ray, circadian rhythm shift, and appetite/dietary changes.
Results: The main findings of this study were: (i) there were significant (all p ≤ .05) reductions in weight, waist circumference and body-fat mass from pre- to post-intervention, but this was independent of group allocation; (ii) no significant differences were noted across any circadian parameters from pre- to post-intervention; (iii) energy intake demonstrated a moderate decrease from pre- to post-intervention, but this did not reach statistical significance.
Conclusion: In contrast to our overarching hypotheses, addition of exercise to eTRF did not result in any additional benefits to any of the parameters measured within this study.
Details
- Title
- Reducing risk factors in individuals at-risk of type 2 diabetes: Combining early-time restricted feeding and multimodal exercise
- Authors/Creators
- Facundo Soto
- Contributors
- Timothy Fairchild (Supervisor) - Murdoch University, Centre for Molecular Medicine and Innovative Therapeutics
- Awarding Institution
- Murdoch University; Masters by Research
- Identifiers
- 991005598469907891
- Murdoch Affiliation
- Centre for Molecular Medicine and Innovative Therapeutics; School of Allied Health
- Resource Type
- Thesis
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