β-Amyloid, APOE and BDNF genotype, and depressive and anxiety symptoms in cognitively normal older women and men

S.E. Holmes; I. Esterlis; C.M. Mazure; Y.Y. Lim; D. Ames; S. Rainey-Smith; R.N. Martins; O. Salvado; V. Doré; V.L. Villemagne; C.C. Rowe; S.M. Laws; C.L. Masters; P. Maruff; R.H. Pietrzak

doi:10.1016/j.jagp.2016.08.007

Back

β-Amyloid, APOE and BDNF genotype, and depressive and anxiety symptoms in cognitively normal older women and men

Journal article

Peer reviewed

β-Amyloid, APOE and BDNF genotype, and depressive and anxiety symptoms in cognitively normal older women and men

S.E. Holmes, I. Esterlis, C.M. Mazure, Y.Y. Lim, D. Ames, S. Rainey-Smith, R.N. Martins, O. Salvado, V. Doré, V.L. Villemagne, …

The American Journal of Geriatric Psychiatry, Vol.24(12), pp.1191-1195

2016

DOI: https://doi.org/10.1016/j.jagp.2016.08.007

Files and links (1)

url

Link to Published Version *Subscription may be requiredView

Abstract

Objective To examine how β-amyloid (Aβ), APOE and BDNF genotypes, and cortisol relate to depressive and anxiety symptoms in cognitively normal older women and men. Methods Cross-sectional data were analyzed from 423 older adults from the Australian Imaging Biomarkers and Lifestyle study. Analyses of covariance evaluated associations between Aβ, APOE and BDNF genotype, and cortisol in relation to severity of depressive and anxiety symptoms. Results Among Aβ+ older adults, APOE ε4 carriage was associated with greater severity of anxiety symptoms (d = 0.55); and in the full sample, APOE ε4 carriage was linked to greater severity of depressive (d = 0.26) and anxiety (d = 0.21) symptoms. Among Aβ+ women, ε4 carriers reported greater anxiety symptoms than non-ε4 carriers (d = 0.83), and female BDNF rs6265 Val66 Met allele carriers reported greater depressive symptoms (d = 0.29). Conclusion Sex moderated the relationship between Aβ, APOE genotype, and BDNF genotype in predicting severity of anxiety and depressive symptoms in cognitively normal older adults.

Details

Title: β-Amyloid, APOE and BDNF genotype, and depressive and anxiety symptoms in cognitively normal older women and men
Authors/Creators: S.E. Holmes (Author/Creator) - Yale University
I. Esterlis (Author/Creator) - Yale University
C.M. Mazure (Author/Creator) - Yale University
Y.Y. Lim (Author/Creator) - Florey Institute of Neuroscience and Mental Health
D. Ames (Author/Creator) - St Vincent's Health
S. Rainey-Smith (Author/Creator)
R.N. Martins (Author/Creator) - Edith Cowan University
O. Salvado (Author/Creator) - Health Sciences and Nutrition
V. Doré (Author/Creator) - Health Sciences and Nutrition
V.L. Villemagne (Author/Creator) - Florey Institute of Neuroscience and Mental Health
C.C. Rowe (Author/Creator) - Austin Health
S.M. Laws (Author/Creator) - Edith Cowan University
C.L. Masters (Author/Creator) - Florey Institute of Neuroscience and Mental Health
P. Maruff (Author/Creator) - Florey Institute of Neuroscience and Mental Health
R.H. Pietrzak (Author/Creator) - Yale University
Publication Details: The American Journal of Geriatric Psychiatry, Vol.24(12), pp.1191-1195
Publisher: Elsevier Inc.
Identifiers: 991005540882207891
Copyright: © 2016 American Association for Geriatric Psychiatry.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

26 Record Views

27 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.60 Dementia
Web Of Science research areas: Geriatrics & Gerontology; Gerontology; Psychiatry
ESI research areas: Psychiatry/Psychology