Journal article
1,3-Phenylene bis(ketoacid) derivatives as inhibitors of Escherichia coli dihydrodipicolinate synthase
Bioorganic & Medicinal Chemistry, Vol.20(7), pp.2419-2426
2012
Abstract
Dihydrodipicolinate synthase is a key enzyme in the lysine biosynthesis pathway that catalyzes the condensation of pyruvate and aspartate semi-aldehyde. A series of phenolic ketoacid derivatives that mimic the proposed enzymatic intermediate were designed as potential inhibitors of this enzyme and were synthesized from simple precursors. The ketoacid derivatives were shown to act as slow and slow-tight binding inhibitors. Mass spectrometric experiments provided further evidence to support the proposed model of inhibition, demonstrating either an encounter complex or a condensation product for the slow and slow-tight binding inhibitors, respectively.
Details
- Title
- 1,3-Phenylene bis(ketoacid) derivatives as inhibitors of Escherichia coli dihydrodipicolinate synthase
- Authors/Creators
- B.A. Boughton (Author/Creator)L. Hor (Author/Creator)J.A. Gerrard (Author/Creator)C.A. Hutton (Author/Creator)
- Publication Details
- Bioorganic & Medicinal Chemistry, Vol.20(7), pp.2419-2426
- Publisher
- Elsevier
- Identifiers
- 991005545510207891
- Copyright
- © 2012 Elsevier Ltd
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 3 Agriculture, Environment & Ecology
- 3.180 Microbial Biotechnology
- 3.180.1184 Amino Acid Biosynthesis
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Medicinal
- Chemistry, Organic
- ESI research areas
- Chemistry