A Novel Blood Proteomic Signature for Prostate Cancer

Ammara Muazzam; Matt Spick; Olivier N F Cexus; Bethany Geary; Fowz Azhar; Hardev Pandha; Agnieszka Michael; Rachel Reed; Sarah Lennon; Lee A Gethings; Robert S Plumb; Anthony D Whetton; Nophar Geifman; Paul A Townsend

doi:10.3390/cancers15041051

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A Novel Blood Proteomic Signature for Prostate Cancer

Journal article

Open access

Peer reviewed

A Novel Blood Proteomic Signature for Prostate Cancer

Ammara Muazzam, Matt Spick, Olivier N F Cexus, Bethany Geary, Fowz Azhar, Hardev Pandha, Agnieszka Michael, Rachel Reed, Sarah Lennon, Lee A Gethings, …

Cancers, Vol.15(4), Art. 1051

2023

DOI: https://doi.org/10.3390/cancers15041051

PMID: 36831393

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Abstract

SWATH-MS

prostate cancer

proteomics

biomarkers

complement cascade

clinical onset

Prostate cancer is the most common malignant tumour in men. Improved testing for diagnosis, risk prediction, and response to treatment would improve care. Here, we identified a proteomic signature of prostate cancer in peripheral blood using data-independent acquisition mass spectrometry combined with machine learning. A highly predictive signature was derived, which was associated with relevant pathways, including the coagulation, complement, and clotting cascades, as well as plasma lipoprotein particle remodeling. We further validated the identified biomarkers against a second cohort, identifying a panel of five key markers (GP5, SERPINA5, ECM1, IGHG1, and THBS1) which retained most of the diagnostic power of the overall dataset, achieving an AUC of 0.91. Taken together, this study provides a proteomic signature complementary to PSA for the diagnosis of patients with localised prostate cancer, with the further potential for assessing risk of future development of prostate cancer. Data are available via ProteomeXchange with identifier PXD025484.

Details

Title: A Novel Blood Proteomic Signature for Prostate Cancer
Authors/Creators: Ammara Muazzam - University of Manchester
Matt Spick - University of Surrey
Olivier N F Cexus - University of Surrey
Bethany Geary - University of Dundee
Fowz Azhar - University of Manchester
Hardev Pandha - University of Surrey
Agnieszka Michael - University of Surrey
Rachel Reed - University of Manchester
Sarah Lennon - Institut de Recherche en Santé, Environnement et Travail
Lee A Gethings - University of Manchester
Robert S Plumb - Murdoch University, Perth, WA 6150, Australia
Anthony D Whetton - University of Surrey
Nophar Geifman - University of Surrey
Paul A Townsend - University of Manchester
Publication Details: Cancers, Vol.15(4), Art. 1051
Grant note: MR/M008959 / Medical Research Council Award 19007 / Blood Cancer UK Male Uprising / Hope for Guernsey Punjab Educational Endowment Fund C5759/A25254 / Cancer Research UK
Identifiers: 991005565369307891
Murdoch Affiliation: Health Futures Institute
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.147 Prostate Cancer; 1.147.97 Prostate Cancer
Web Of Science research areas: Oncology
ESI research areas: Clinical Medicine