A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1

J. Fellay; K.V. Shianna; D. Ge; S. Colombo; B. Ledergerber; M. Weale; K. Zhang; C. Gumbs; A. Castagna; A. Cossarizza; A. Cozzi-Lepri; A. De Luca; P. Easterbrook; P. Francioli; S. Mallal; J. Martinez-Picado; J.M. Miro; N. Obel; J. P. Smith; J. Wyniger; P. Descombes; S.E. Antonarakis; N.L. Letvin; A.J. McMichael; B.F. Haynes; A. Telenti; D.B. Goldstein

doi:10.1126/science.1143767

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A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1

Journal article

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A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1

J. Fellay, K.V. Shianna, D. Ge, S. Colombo, B. Ledergerber, M. Weale, K. Zhang, C. Gumbs, A. Castagna, A. Cossarizza, …

Science, Vol.317(5840), pp.944-947

17/08/2007

DOI: https://doi.org/10.1126/science.1143767

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Abstract

Understanding why some people establish and maintain effective control of HIV-1 and others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole-genome association strategy, we identified polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection. One of these is found within an endogenous retroviral element and is associated with major histocompatibility allele human leukocyte antigen (HLA)-B*5701, whereas a second is located near the HLA-C gene. An additional analysis of the time to HIV disease progression implicated two genes, one of which encodes an RNA polymerase I subunit. These findings emphasize the importance of studying human genetic variation as a guide to combating infectious agents.

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Title: A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1
Authors/Creators: J. Fellay (Author/Creator) - Duke University
K.V. Shianna (Author/Creator) - Duke University
D. Ge (Author/Creator) - Duke University
S. Colombo (Author/Creator) - University of Lausanne
B. Ledergerber (Author/Creator) - University of Zurich
M. Weale (Author/Creator) - Duke University
K. Zhang (Author/Creator) - University of Lausanne
C. Gumbs (Author/Creator) - Duke University
A. Castagna (Author/Creator) - IRCCS Ospedale San Raffaele
A. Cossarizza (Author/Creator) - University of Modena and Reggio Emilia
A. Cozzi-Lepri (Author/Creator) - University College London
A. De Luca (Author/Creator) - Università Cattolica del Sacro Cuore
P. Easterbrook (Author/Creator) - King's College London
P. Francioli (Author/Creator) - University of Lausanne
S. Mallal (Author/Creator) - Murdoch University
J. Martinez-Picado (Author/Creator) - ICREA
J.M. Miro (Author/Creator) - Universitat de Barcelona
N. Obel (Author/Creator) - University of Copenhagen
J. P. Smith (Author/Creator) - Duke University
J. Wyniger (Author/Creator) - University of Lausanne
P. Descombes (Author/Creator) - University of Geneva
S.E. Antonarakis (Author/Creator) - University of Geneva
N.L. Letvin (Author/Creator) - Harvard University
A.J. McMichael (Author/Creator) - John Radcliffe Hospital
B.F. Haynes (Author/Creator) - Duke University
A. Telenti (Author/Creator) - University of Lausanne
D.B. Goldstein (Author/Creator) - Duke University
Publication Details: Science, Vol.317(5840), pp.944-947
Publisher: American Association for the Advancement of Science
Identifiers: 991005540863507891
Murdoch Affiliation: Centre for Clinical Immunology and Biomedical Statistics
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.66 HIV; 1.66.46 HIV Pathogenesis
Web Of Science research areas: Immunology
ESI research areas: Immunology