Journal article
A brief comparative look at experimental memory editing techniques for cognitive dysfunction
Current Alzheimer Research, Vol.18(10), pp.841-848
2021
Abstract
Neuroscience has long sought to develop methods that can “edit” or even “erase” memories, with the aim to provide treatments for memory-related neurological and psychiatric diseases such as anxiety and addiction. Current efforts are heavily focused on modifying cognitive behavioral therapy protocols or pharmacological treatments, but the efficacy and safety of these methods have been called into question by several studies. Advances in modern technology and the rapid emergence of techniques that can directly stimulate/alter neuronal activity, such as neuromodulation, have great potential in achieving the goal of memory modification for treating dementia such as Alzheimer’s disease. However, more research and validation studies are required before these memory editing technologies can be applied clinically. In this mini-review, we compare and highlight the advantages and disadvantages of cognitive behavioral therapy, pharmacological methods, and neuromodulation techniques. We believe that neuromodulation techniques will play a key role in overcoming the challenges of translating memory-manipulating techniques to clinical applications.
Details
- Title
- A brief comparative look at experimental memory editing techniques for cognitive dysfunction
- Authors/Creators
- C.H. Poon (Author/Creator) - University of Hong KongS.Z.K. Tan (Author/Creator) - University of Hong KongV. Sheng (Author/Creator) - University of Hong KongS. Wang (Author/Creator) - Fudan UniversityL. Aquili (Author/Creator) - Charles Darwin UniversityL.W. Lim (Author/Creator) - University of Hong Kong
- Publication Details
- Current Alzheimer Research, Vol.18(10), pp.841-848
- Publisher
- Bentham Science Publishers
- Identifiers
- 991005545291607891
- Copyright
- © 2021 Bentham Science Publishers
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.5 Neuroscience
- 1.5.1090 Fear Conditioning
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior