A chromosome conformation capture ordered sequence of the barley genome

M. Mascher; H. Gundlach; A. Himmelbach; S. Beier; S.O. Twardziok; T. Wicker; V. Radchuk; C. Dockter; P.E. Hedley; J. Russell; M. Bayer; L. Ramsay; H. Liu; G. Haberer; X-Q Zhang; Q. Zhang; R.A. Barrero; L. Li; S. Taudien; M. Groth; M. Felder; A. Hastie; H. Šimková; H. Staňková; J. Vrána; S. Chan; M. Muñoz-Amatriaín; R. Ounit; S. Wanamaker; D. Bolser; C. Colmsee; T. Schmutzer; L. Aliyeva-Schnorr; S. Grasso; J. Tanskanen; A. Chailyan; D. Sampath; D. Heavens; L. Clissold; S. Cao; B. Chapman; F. Dai; Y. Han; H. Li; X. Li; C. Lin; J.K. McCooke; C. Tan; P. Wang; S. Wang; S. Yin; G. Zhou; J.A. Poland; M.I. Bellgard; L. Borisjuk; A. Houben; J. Doležel; S. Ayling; S. Lonardi; P. Kersey; P. Langridge; G.J. Muehlbauer; M.D. Clark; M. Caccamo; A.H. Schulman; K.F.X. Mayer; M. Platzer; T.J. Close; U. Scholz; M. Hansson; G. Zhang; I. Braumann; M. Spannagl; C. Li; R. Waugh; N. Stein

doi:10.1038/nature22043

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A chromosome conformation capture ordered sequence of the barley genome

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A chromosome conformation capture ordered sequence of the barley genome

M. Mascher, H. Gundlach, A. Himmelbach, S. Beier, S.O. Twardziok, T. Wicker, V. Radchuk, C. Dockter, P.E. Hedley, J. Russell, …

Nature, Vol.544(7651), pp.427-433

2017

DOI: https://doi.org/10.1038/nature22043

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Abstract

Cereal grasses of the Triticeae tribe have been the major food source in temperate regions since the dawn of agriculture. Their large genomes are characterized by a high content of repetitive elements and large pericentromeric regions that are virtually devoid of meiotic recombination. Here we present a high-quality reference genome assembly for barley (Hordeum vulgare L.). We use chromosome conformation capture mapping to derive the linear order of sequences across the pericentromeric space and to investigate the spatial organization of chromatin in the nucleus at megabase resolution. The composition of genes and repetitive elements differs between distal and proximal regions. Gene family analyses reveal lineage-specific duplications of genes involved in the transport of nutrients to developing seeds and the mobilization of carbohydrates in grains. We demonstrate the importance of the barley reference sequence for breeding by inspecting the genomic partitioning of sequence variation in modern elite germplasm, highlighting regions vulnerable to genetic erosion.

Details

Title: A chromosome conformation capture ordered sequence of the barley genome
Authors/Creators: M. Mascher (Author/Creator)
H. Gundlach (Author/Creator)
A. Himmelbach (Author/Creator)
S. Beier (Author/Creator)
S.O. Twardziok (Author/Creator)
T. Wicker (Author/Creator)
V. Radchuk (Author/Creator)
C. Dockter (Author/Creator)
P.E. Hedley (Author/Creator)
J. Russell (Author/Creator)
M. Bayer (Author/Creator)
L. Ramsay (Author/Creator)
H. Liu (Author/Creator)
G. Haberer (Author/Creator)
X-Q Zhang (Author/Creator)
Q. Zhang (Author/Creator)
R.A. Barrero (Author/Creator)
L. Li (Author/Creator)
S. Taudien (Author/Creator)
M. Groth (Author/Creator)
M. Felder (Author/Creator)
A. Hastie (Author/Creator)
H. Šimková (Author/Creator)
H. Staňková (Author/Creator)
J. Vrána (Author/Creator)
S. Chan (Author/Creator)
M. Muñoz-Amatriaín (Author/Creator)
R. Ounit (Author/Creator)
S. Wanamaker (Author/Creator)
D. Bolser (Author/Creator)
C. Colmsee (Author/Creator)
T. Schmutzer (Author/Creator)
L. Aliyeva-Schnorr (Author/Creator)
S. Grasso (Author/Creator)
J. Tanskanen (Author/Creator)
A. Chailyan (Author/Creator)
D. Sampath (Author/Creator)
D. Heavens (Author/Creator)
L. Clissold (Author/Creator)
S. Cao (Author/Creator)
B. Chapman (Author/Creator)
F. Dai (Author/Creator)
Y. Han (Author/Creator)
H. Li (Author/Creator)
X. Li (Author/Creator)
C. Lin (Author/Creator)
J.K. McCooke (Author/Creator)
C. Tan (Author/Creator)
P. Wang (Author/Creator)
S. Wang (Author/Creator)
S. Yin (Author/Creator)
G. Zhou (Author/Creator)
J.A. Poland (Author/Creator)
M.I. Bellgard (Author/Creator)
L. Borisjuk (Author/Creator)
A. Houben (Author/Creator)
J. Doležel (Author/Creator)
S. Ayling (Author/Creator)
S. Lonardi (Author/Creator)
P. Kersey (Author/Creator)
P. Langridge (Author/Creator)
G.J. Muehlbauer (Author/Creator)
M.D. Clark (Author/Creator)
M. Caccamo (Author/Creator)
A.H. Schulman (Author/Creator)
K.F.X. Mayer (Author/Creator)
M. Platzer (Author/Creator)
T.J. Close (Author/Creator)
U. Scholz (Author/Creator)
M. Hansson (Author/Creator)
G. Zhang (Author/Creator)
I. Braumann (Author/Creator)
M. Spannagl (Author/Creator)
C. Li (Author/Creator)
R. Waugh (Author/Creator)
N. Stein (Author/Creator)
Publication Details: Nature, Vol.544(7651), pp.427-433
Identifiers: 991005544228007891
Murdoch Affiliation: School of Veterinary and Life Sciences; Centre for Comparative Genomics
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 3 Agriculture, Environment & Ecology; 3.4 Crop Science; 3.4.96 QTL
Web Of Science research areas: Biochemistry & Molecular Biology
ESI research areas: Molecular Biology & Genetics