Journal article
A comparison of eosinopenia and C-reactive protein and as a marker of bloodstream infections in critically ill patients: A case control study
Anaesthesia and Intensive Care, Vol.37(3), pp.450-456
2009
Abstract
Diagnosis of bloodstream infections in critically ill patients is difficult. This case control study involved a total of 22 patients with confirmed bloodstream infections and 44 concurrent controls from an intensive care unit in Western Australia. We aimed to assess whether eosinopenia and C-reactive protein are useful markers of bloodstream infections in critically ill patients. The patients with bloodstream infections had a more severe disease and a longer length of intensive care unit (10.7 vs 4.0 days, P=0.001) and hospital stay (40.9 vs 17.9 days, P=0.015) than the controls. Univariate analyses showed that C-reactive protein (area under the receiver operating characteristic curve 0.847, 95% confidence interval (CI) 0.721 to 0.973), eosinophil counts (area under the receiver operating characteristic curve 0.849, 95% CI 0.738 to 0.961) and fibrinogen concentrations (area under the receiver operating characteristic curve 0.730, 95% CI 0.578 to 0.882) were significant markers of bloodstream infections. C-reactive protein concentration was, however, the only significant predictor in the multivariate analysis (odds ratio 1.21 per 10 mg/l increment, 95% CI 1.01 to 1.39, P=0.007). C-reactive protein concentration appears to be a better marker of bloodstream infections than eosinopenia in critically ill patients. A large prospective cohort study is needed to assess whether eosinopenia is useful in addition to C-reactive protein concentrations as a marker of bloodstream infections.
Details
- Title
- A comparison of eosinopenia and C-reactive protein and as a marker of bloodstream infections in critically ill patients: A case control study
- Authors/Creators
- K.M. Ho (Author/Creator)S.C. Towler (Author/Creator)
- Publication Details
- Anaesthesia and Intensive Care, Vol.37(3), pp.450-456
- Publisher
- Australian Society of Anaesthetists
- Number of pages
- 7
- Identifiers
- 991005544126707891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Web Of Science research areas
- Anesthesiology
- Critical Care Medicine
- ESI research areas
- Clinical Medicine