A comparison of high-frequency jet ventilation and synchronised intermittent mandatory ventilation in preterm lambs

G.C. Musk; G.R. Polglase; J.B. Bunnell; I. Nitsos; D. Tingay; J.J. Pillow

doi:10.1002/ppul.23187

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A comparison of high-frequency jet ventilation and synchronised intermittent mandatory ventilation in preterm lambs

Journal article

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Peer reviewed

A comparison of high-frequency jet ventilation and synchronised intermittent mandatory ventilation in preterm lambs

G.C. Musk, G.R. Polglase, J.B. Bunnell, I. Nitsos, D. Tingay and J.J. Pillow

Pediatric Pulmonology, Vol.50(12), pp.1286-1293

2015

DOI: https://doi.org/10.1002/ppul.23187

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Abstract

Purpose: Synchronised intermittent mandatory ventilation (SIMV) and high-frequency jet ventilation (HFJV) are accepted ventilatory strategies for treatment of respiratory distress syndrome (RDS) in preterm babies. We hypothesised that SIMV and HFJV both facilitate adequate oxygenation and ventilation but that HFJV is associated with less lung injury. Results: There were no differences in arterial oxygenation or partial pressure of carbon dioxide despite lower mean airway pressure during SIMV for most of the study. There were no consistent significant differences in end systolic and end diastolic PBF, lung injury data and static lung compliance. Methods: Preterm lambs of anaesthetised ewes were instrumented, intubated and delivered by caesarean section after intratracheal suction and instillation of surfactant. Each lamb was managed for 3 hr according to a predetermined algorithm for ventilatory support consistent with open lung ventilation. Pulmonary blood flow (PBF) was measured continuously and pulsatility index was calculated. Ventilatory parameters were recorded and arterial blood gases were measured at intervals. At postmortem, in situ pressure-volume deflation curves were recorded, and bronchoalveolar lavage fluid and lung tissue were obtained to assess inflammation. Conclusions: SIMV and HFJV have comparable clinical efficacy and ventilator pressure requirements when applied with a targeted lung volume recruitment strategy.

Details

Title: A comparison of high-frequency jet ventilation and synchronised intermittent mandatory ventilation in preterm lambs
Authors/Creators: G.C. Musk (Author/Creator) - The University of Western Australia
G.R. Polglase (Author/Creator) - Monash Institute of Medical Research
J.B. Bunnell (Author/Creator) - Bunnell (United States)
I. Nitsos (Author/Creator) - Monash Institute of Medical Research
D. Tingay (Author/Creator) - Murdoch Children's Research Institute
J.J. Pillow (Author/Creator) - The University of Western Australia
Publication Details: Pediatric Pulmonology, Vol.50(12), pp.1286-1293
Publisher: Wiley-Blackwell
Identifiers: 991005540047107891
Copyright: © 2015 Wiley Periodicals
Murdoch Affiliation: School of Veterinary and Life Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.154 Assisted Ventilation; 1.154.277 Mechanical Ventilation
Web Of Science research areas: Pediatrics; Respiratory System
ESI research areas: Clinical Medicine