Journal article
A correlation between HLA-C matching and donor antirecipient CTL precursor frequency in bone marrow transplantation
Transplantation, Vol.61(9), pp.1420-1423
1996
Abstract
A newly developed, reliable, DNA-based method for typing for alleles of the HLA-C locus has been applied in the context of unrelated, volunteer donors for bone marrow transplantation. Some donors matched for HLA-A, -B, -DR, and -DQ have been found to generate in vitro high frequencies of CTL reactive with the recipient's cells. Here we demonstrate that there is a highly significant correlation of the frequencies of CTL precursors and incompatibility at the HLA-C locus. These data indicate that HLA-C locus incompatibility should be avoided in unrelated donor bone marrow transplantation.
Details
- Title
- A correlation between HLA-C matching and donor antirecipient CTL precursor frequency in bone marrow transplantation
- Authors/Creators
- M.C.N.M. Barnardo (Author/Creator)N.J. Davey (Author/Creator)M. Bunce (Author/Creator)P.A. Brookes (Author/Creator)R.I. Lechler (Author/Creator)K.I. Welsh (Author/Creator)J.R. Batchelor (Author/Creator)
- Publication Details
- Transplantation, Vol.61(9), pp.1420-1423
- Publisher
- Lippincott, Williams & Wilkins
- Identifiers
- 991005543414507891
- Copyright
- 1996 Williams & Wilkins
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.103 Blood Disorders
- 1.103.380 GvHD
- Web Of Science research areas
- Immunology
- Surgery
- Transplantation
- ESI research areas
- Clinical Medicine