A decade of progress in deep brain stimulation of the subcallosal cingulate for the treatment of depression

S. Khairuddin; F.Y. Ngo; W.L. Lim; L. Aquili; N.A. Khan; M-L Fung; Y-S Chan; Y. Temel; L.W. Lim

doi:10.3390/jcm9103260

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A decade of progress in deep brain stimulation of the subcallosal cingulate for the treatment of depression

Journal article

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Peer reviewed

A decade of progress in deep brain stimulation of the subcallosal cingulate for the treatment of depression

S. Khairuddin, F.Y. Ngo, W.L. Lim, L. Aquili, N.A. Khan, M-L Fung, Y-S Chan, Y. Temel and L.W. Lim

Journal of Clinical Medicine, Vol.9(10), Art. 3260

2020

DOI: https://doi.org/10.3390/jcm9103260

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Abstract

Major depression contributes significantly to the global disability burden. Since the first clinical study of deep brain stimulation (DBS), over 446 patients with depression have now undergone this neuromodulation therapy, and 29 animal studies have investigated the efficacy of subgenual cingulate DBS for depression. In this review, we aim to provide a comprehensive overview of the progress of DBS of the subcallosal cingulate in humans and the medial prefrontal cortex, its rodent homolog. For preclinical animal studies, we discuss the various antidepressant-like behaviors induced by medial prefrontal cortex DBS and examine the possible mechanisms including neuroplasticity-dependent/independent cellular and molecular changes. Interestingly, the response rate of subcallosal cingulate Deep brain stimulation marks a milestone in the treatment of depression. DBS achieved response and remission rates of 64–76% and 37–63%, respectively, from clinical studies monitoring patients from 6–24 months. Although some studies showed its stimulation efficacy was limited, it still holds great promise as a therapy for patients with treatment-resistant depression. Overall, further research is still needed, including more credible clinical research, preclinical mechanistic studies, precise selection of patients, and customized electrical stimulation paradigms.

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Title: A decade of progress in deep brain stimulation of the subcallosal cingulate for the treatment of depression
Authors/Creators: S. Khairuddin (Author/Creator) - University of Hong Kong
F.Y. Ngo (Author/Creator) - University of Hong Kong
W.L. Lim (Author/Creator) - Sunway University
L. Aquili (Author/Creator)
N.A. Khan (Author/Creator)
M-L Fung (Author/Creator) - University of Hong Kong
Y-S Chan (Author/Creator) - University of Hong Kong
Y. Temel (Author/Creator) - Maastricht University
L.W. Lim (Author/Creator) - Sunway University
Publication Details: Journal of Clinical Medicine, Vol.9(10), Art. 3260
Publisher: MDPI
Identifiers: 991005543119107891
Copyright: © 2020 The Authors.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.21 Psychiatry; 1.21.952 Obsessive-Compulsive Disorder
Web Of Science research areas: Neurosciences
ESI research areas: Clinical Medicine