Logo image
Back
A depressive endophenotype of poorer cognition among cognitively healthy community-dwelling adults: Results from the Western Australia memory study
Journal article   Peer reviewed

A depressive endophenotype of poorer cognition among cognitively healthy community-dwelling adults: Results from the Western Australia memory study

L.A. Johnson, H.R. Sohrabi, J.R. Hall, K. Taddei, M. Edwards, S.E. O'Bryant and R.N. Martins
International Journal of Geriatric Psychiatry, Vol.30(8), pp.881-886
2014
DOI: https://doi.org/10.1002/gps.4231
url
Link to Published Version *Subscription may be requiredView

Abstract

Objective The objective was to evaluate in a cognitively normal population the utility of an endophenotype of the depression–cognition link previously shown to be related to cognitive functioning in mild cognitive impairment and Alzheimer's disease. Methods The data of 460 cognitively normal adults aged 32–92 years (M = 63.5, standard deviation = 9.24) from the Western Australian Memory Study with the Cross‐national comparisons of the Cambridge Cognitive Examination‐revised (CAMCOG‐R) scores and 30‐item Geriatric Depression Scale (GDS) scores were analyzed to determine the relationship between the five‐item depressive endophenotype (DepE) scale drawn from the GDS and level of performance on a measure of cognitive functioning. Results For the entire sample, there was a nonsignificant trend toward a negative relationship between DepE and CAMCOG‐R scores. When analyzed for those 65 years and older, there was a significant negative relationship between the two measures (p = 0.001) with DepE scores significantly increasing the risk for performing more poorly on the CAMCOG‐R (odds ratio = 1.53). Analysis of data for those 70 years and older showed that DepE was the only predictor significantly related to poorer CAMCOG‐R performance (p = 0.001). For the 70 years and older group, DepE scores significantly increased the risk of poorer CAMCOG‐R scores (odds ratio = 2.23). Analysis of the entire sample on the basis of ApoEε4 carrier status revealed that DepE scores were significantly negatively related only to ApoEε4 noncarrier regardless of age. Conclusions Elevated DepE scores are associated with poor neuropsychological performance among cognitively normal older adults. Use of the DepE may allow for the identification of a subset of older adults where depression is a primary factor in cognitive decline and who may benefit from antidepressant therapies.

Details

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

Source: InCites

Metrics

28 Record Views
12 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types
Domestic collaboration
International collaboration
Citation topics
1 Clinical & Life Sciences
1.52 Neurodegenerative Diseases
1.52.60 Dementia
Web Of Science research areas
Geriatrics & Gerontology
Gerontology
Psychiatry
ESI research areas
Psychiatry/Psychology
Logo image