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Journal article
A field guide to pandemic, epidemic and sporadic clones of methicillin-resistant Staphylococcus aureus
PLoS ONE, Vol.6(4), e17936
2011
Abstract
In recent years, methicillin-resistant Staphylococcus aureus (MRSA) have become a truly global challenge. In addition to the long-known healthcare-associated clones, novel strains have also emerged outside of the hospital settings, in the community as well as in livestock. The emergence and spread of virulent clones expressing Panton-Valentine leukocidin (PVL) is an additional cause for concern. In order to provide an overview of pandemic, epidemic and sporadic strains, more than 3,000 clinical and veterinary isolates of MRSA mainly from Germany, the United Kingdom, Ireland, France, Malta, Abu Dhabi, Hong Kong, Australia, Trinidad & Tobago as well as some reference strains from the United States have been genotyped by DNA microarray analysis. This technique allowed the assignment of the MRSA isolates to 34 distinct lineages which can be clearly defined based on non-mobile genes. The results were in accordance with data from multilocus sequence typing. More than 100 different strains were distinguished based on affiliation to these lineages, SCCmec type and the presence or absence of PVL. These strains are described here mainly with regard to clinically relevant antimicrobial resistance- and virulence-associated markers, but also in relation to epidemiology and geographic distribution. The findings of the study show a high level of biodiversity among MRSA, especially among strains harbouring SCCmec IV and V elements. The data also indicate a high rate of genetic recombination in MRSA involving SCC elements, bacteriophages or other mobile genetic elements and large-scale chromosomal replacements.
Details
- Title
- A field guide to pandemic, epidemic and sporadic clones of methicillin-resistant Staphylococcus aureus
- Authors/Creators
- S. Monecke (Author/Creator) - Technische Universität DresdenG. Coombs (Author/Creator) - Royal Perth HospitalA.C. Shore (Author/Creator) - Dublin Dental University HospitalD.C. Coleman (Author/Creator) - Dublin Dental University HospitalP. Akpaka (Author/Creator) - University of the West IndiesM. Borg (Author/Creator) - Mater Dei HospitalH. Chow (Author/Creator) - Chinese University of Hong KongM. Ip (Author/Creator) - Chinese University of Hong KongL. Jatzwauk (Author/Creator) - Technische Universität DresdenD. Jonas (Author/Creator) - University Medical Center FreiburgK. Kadlec (Author/Creator) - Friedrich-Loeffler-InstitutA. Kearns (Author/Creator) - Health Protection AgencyF. Laurent (Author/Creator) - Université de LyonF.G. O'Brien (Author/Creator) - Curtin UniversityJ. Pearson (Author/Creator) - Royal Perth HospitalA. Ruppelt (Author/Creator) - Technische Universität DresdenS. Schwarz (Author/Creator) - Friedrich-Loeffler-InstitutE. Scicluna (Author/Creator) - Mater Dei HospitalP. Slickers (Author/Creator) - Alere (Germany)H-L Tan (Author/Creator) - Royal Perth HospitalS. Weber (Author/Creator) - Shaikh Khalifa Medical CityR. Ehricht (Author/Creator) - Alere (Germany)
- Publication Details
- PLoS ONE, Vol.6(4), e17936
- Publisher
- Public Library of Science
- Identifiers
- 991005545465307891
- Copyright
- © 2011 Monecke et al.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.23 Antibiotics & Antimicrobials
- 1.23.173 MRSA and VRE
- Web Of Science research areas
- Microbiology
- ESI research areas
- Microbiology