A fluid–structure interaction study using patient-specific ruptured and unruptured aneurysm: The effect of aneurysm morphology, hypertension and elasticity

C-J Lee; Y. Zhang; H. Takao; Y. Murayama; Y. Qian

doi:10.1016/j.jbiomech.2013.07.016

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A fluid–structure interaction study using patient-specific ruptured and unruptured aneurysm: The effect of aneurysm morphology, hypertension and elasticity

Journal article

Peer reviewed

A fluid–structure interaction study using patient-specific ruptured and unruptured aneurysm: The effect of aneurysm morphology, hypertension and elasticity

C-J Lee, Y. Zhang, H. Takao, Y. Murayama and Y. Qian

Journal of Biomechanics, Vol.46(14), pp.2402-2410

2013

DOI: https://doi.org/10.1016/j.jbiomech.2013.07.016

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Abstract

Fluid–structure interaction (FSI) simulations using five patient-specific aneurysm geometries are carried out to investigate the difference between ruptured and unruptured aneurysms. Two different blood pressure conditions (normal and hypertension, for all cases), and two different values of elastic modulus (1 and 2 MPa, for two cases) are tested. Ruptured aneurysms (RA) generally displayed larger displacement at the dome, lower area–average WSS and higher von Mises stress than unruptured aneurysms (URA) regardless of elasticity or blood pressure condition. RAs had a longitudinal expansion whereas URAs had a radial expansion, which was the key difference between the two types. The difference in expansion pattern may be one of the keys to explaining aneurysm rupture, and further analysis is required in the future to confirm this theory.

Details

Title: A fluid–structure interaction study using patient-specific ruptured and unruptured aneurysm: The effect of aneurysm morphology, hypertension and elasticity
Authors/Creators: C-J Lee (Author/Creator) - Australian School of Advanced Medicine
Y. Zhang (Author/Creator) - Australian School of Advanced Medicine
H. Takao (Author/Creator) - Jikei University School of Medicine
Y. Murayama (Author/Creator) - Jikei University School of Medicine
Y. Qian (Author/Creator) - Australian School of Advanced Medicine
Publication Details: Journal of Biomechanics, Vol.46(14), pp.2402-2410
Publisher: Elsevier
Identifiers: 991005542007707891
Copyright: © 2013 Elsevier Ltd
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.105 Strokes; 1.105.514 Subarachnoid Hemorrhage
Web Of Science research areas: Biophysics; Engineering, Biomedical
ESI research areas: Molecular Biology & Genetics