A genome-wide association study of testicular germ cell tumor

E.A. Rapley; C. Turnbull; A.A. Al Olama; E.T. Dermitzakis; R. Linger; R.A. Huddart; A. Renwick; D. Hughes; S. Hines; S. Seal; J. Morrison; J. Nsengimana; P. Deloukas; N. Rahman; D.T. Bishop; D.F. Easton; M.R. Stratton; D. Perera

doi:10.1038/ng.394

Back

A genome-wide association study of testicular germ cell tumor

Journal article

Peer reviewed

A genome-wide association study of testicular germ cell tumor

E.A. Rapley, C. Turnbull, A.A. Al Olama, E.T. Dermitzakis, R. Linger, R.A. Huddart, A. Renwick, D. Hughes, S. Hines, S. Seal, …

Nature Genetics, Vol.41(7), pp.807-810

2009

DOI: https://doi.org/10.1038/ng.394

Files and links (1)

url

Link to Published Version *Subscription may be requiredView

Abstract

We conducted a genome-wide association study for testicular germ cell tumor (TGCT), genotyping 307,666 SNPs in 730 cases and 1,435 controls from the UK and replicating associations in a further 571 cases and 1,806 controls. We found strong evidence for susceptibility loci on chromosome 5 (per allele OR = 1.37 (95% CI = 1.19–1.58), P = 3 times 10-13), chromosome 6 (OR = 1.50 (95% CI = 1.28–1.75), P = 10-13) and chromosome 12 (OR = 2.55 (95% CI = 2.05–3.19), P = 10-31). KITLG, encoding the ligand for the receptor tyrosine kinase KIT, which has previously been implicated in the pathogenesis of TGCT and the biology of germ cells, may explain the association on chromosome 12.

Details

Title: A genome-wide association study of testicular germ cell tumor
Authors/Creators: E.A. Rapley (Author/Creator) - Institute of Cancer Research
C. Turnbull (Author/Creator) - Institute of Cancer Research
A.A. Al Olama (Author/Creator) - Cancer Research UK
E.T. Dermitzakis (Author/Creator) - Wellcome Sanger Institute
R. Linger (Author/Creator) - Institute of Cancer Research
R.A. Huddart (Author/Creator) - Institute of Cancer Research
A. Renwick (Author/Creator) - Institute of Cancer Research
D. Hughes (Author/Creator) - Institute of Cancer Research
S. Hines (Author/Creator) - Institute of Cancer Research
S. Seal (Author/Creator) - Institute of Cancer Research
J. Morrison (Author/Creator) - Cancer Research UK
J. Nsengimana (Author/Creator) - University of Leeds
P. Deloukas (Author/Creator) - Wellcome Sanger Institute
N. Rahman (Author/Creator) - Institute of Cancer Research
D.T. Bishop (Author/Creator) - University of Leeds
D.F. Easton (Author/Creator) - Cancer Research UK
M.R. Stratton (Author/Creator) - Wellcome Sanger Institute
D. Perera (Author/Creator)
Publication Details: Nature Genetics, Vol.41(7), pp.807-810
Publisher: Nature Publishing Group
Identifiers: 991005541024507891
Copyright: © 2009 Macmillan Publishers Limited, part of Springer Nature
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article
Additional Information: Devindri Perera appears courtesy of The Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene)

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

32 Record Views

259 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.291 Testicular Diseases; 1.291.779 Testicular Cancer
Web Of Science research areas: Genetics & Heredity
ESI research areas: Molecular Biology & Genetics