Journal article
A human sensory pathway connecting the foot to ipsilateral face that partially bypasses the spinal cord
Frontiers in Neuroscience, Vol.13, Article 519
2019
Abstract
Human sensory transmission from limbs to brain crosses and ascends through the spinal cord. Yet, descriptions exist of ipsilateral sensory transmission as well as transmission after spinal cord transection. To elucidate a novel ipsilateral cutaneous pathway, we measured facial perfusion following painfully-cold water foot immersion in 10 complete spinal cord-injured patients, 10 healthy humans before and after lower thigh capsaicin C-fiber cutaneous conduction blockade, and 10 warm-immersed healthy participants. As in healthy volunteers, ipsilateral facial perfusion in spinal cord injured patients increased significantly. Capsaicin resulted in contralateral increase in perfusion, but only following cold immersion and not in 2 spinal cord-injured patients who underwent capsaicin administration. Supported by skin biopsy results from a healthy participant, we speculate that the pathway involves peripheral C-fiber cross-talk, partially bypassing the cord. This might also explain referred itch and jogger's migraine and it is possible that it may be amenable to training spinal-injured patients to recognize lower limb sensory stimuli.
Details
- Title
- A human sensory pathway connecting the foot to ipsilateral face that partially bypasses the spinal cord
- Authors/Creators
- M. Silberstein (Author/Creator) - Curtin UniversityA.K. Nunn (Author/Creator) - Austin HealthP.D. Drummond (Author/Creator) - Murdoch UniversityD.W.L. Wan (Author/Creator) - RMIT UniversityJ. Alexander (Author/Creator) - Austin HealthM. Millard (Author/Creator) - Austin HealthM.P. Galea (Author/Creator) - The University of Melbourne
- Publication Details
- Frontiers in Neuroscience, Vol.13, Article 519
- Publisher
- Frontiers Media
- Identifiers
- 991005540262507891
- Copyright
- © 2019 The Author(s)
- Murdoch Affiliation
- School of Psychology and Exercise Science
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.43 Anesthesiology
- 1.43.135 Neuropathic Pain
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior