A new pair of HLA-C alleles, Cw* 12042 and Cw*1203, differing at the KIR-related dimorphism of codons 77-80

C. Vilches; M. Bunce; M. Dam; R. Pablo

doi:10.1111/j.1399-0039.1998.tb02953.x

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A new pair of HLA-C alleles, Cw* 12042 and Cw*1203, differing at the KIR-related dimorphism of codons 77-80

Journal article

Peer reviewed

A new pair of HLA-C alleles, Cw* 12042 and Cw*1203, differing at the KIR-related dimorphism of codons 77-80

C. Vilches, M. Bunce, M. Dam and R. Pablo

Tissue Antigens, Vol.51(1), pp.101-105

1998

DOI: https://doi.org/10.1111/j.1399-0039.1998.tb02953.x

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Abstract

A previously unknown HLA-C variant of the Cw*12 group was identified by PCR-SSP from genomic DNA of cell NDS-JD. Molecular cloning and nucleotide sequence analysis permitted the characterization of the complete coding region of this new allele, Cw*12042. The new variant differs from the recently reported Cw*12041 by two silent changes at exons 2 and 3, and from Cw*1203 by coding changes at codons 77 and 80. Cw*1203 (Ser-Asn) and Cw*12042 (Asn-Lys) constitute the second known example of HLA-C alleles only differing at the KIR-related dimorphism of residues 77–80. The new allele is associated in cell NDS-JD with the haplotype HLA-A*2403, Cw*12042, B*51, DRB1*1502, DRB5*0102, DQB1*0601, possibly related from the evolutionary aspect to the ancestral haplotype A*2402, Cw*1202, B*5201, DRB1*1502, DRB5*0102, DQBl*0601.

Details

Title: A new pair of HLA-C alleles, Cw* 12042 and Cw*1203, differing at the KIR-related dimorphism of codons 77-80
Authors/Creators: C. Vilches (Author/Creator) - Hospital Universitario Puerta de Hierro Majadahonda
M. Bunce (Author/Creator) - Churchill Hospital
M. Dam (Author/Creator)
R. Pablo (Author/Creator)
Publication Details: Tissue Antigens, Vol.51(1), pp.101-105
Publisher: Blackwell Publishing
Identifiers: 991005544045407891
Copyright: 1998 Munksgaard
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.6 Immunology; 1.6.607 MHC Diversity
Web Of Science research areas: Cell Biology; Immunology; Pathology
ESI research areas: Molecular Biology & Genetics