A paradoxical vasodilatory nutraceutical intervention for prevention and attenuation of migraine—A hypothetical review

D.R. Chaliha; M. Vaccarezza; R. Takechi; V. Lam; E. Visser; P. Drummond; J.C.L. Mamo

doi:10.3390/nu12082487

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A paradoxical vasodilatory nutraceutical intervention for prevention and attenuation of migraine—A hypothetical review

Journal article

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A paradoxical vasodilatory nutraceutical intervention for prevention and attenuation of migraine—A hypothetical review

D.R. Chaliha, M. Vaccarezza, R. Takechi, V. Lam, E. Visser, P. Drummond and J.C.L. Mamo

Nutrients, Vol.12(8), Article 2487

2020

DOI: https://doi.org/10.3390/nu12082487

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Abstract

Studies suggest that migraine pain has a vascular component. The prevailing dogma is that peripheral vasoconstriction activates baroreceptors in central, large arteries. Dilatation of central vessels stimulates nociceptors and induces cortical spreading depression. Studies investigating nitric oxide (NO) donors support the indicated hypothesis that pain is amplified when acutely administered. In this review, we provide an alternate hypothesis which, if substantiated, may provide therapeutic opportunities for attenuating migraine frequency and severity. We suggest that in migraines, heightened sympathetic tone results in progressive central microvascular constriction. Suboptimal parenchymal blood flow, we suggest, activates nociceptors and triggers headache pain onset. Administration of NO donors could paradoxically promote constriction of the microvasculature as a consequence of larger upstream central artery vasodilatation. Inhibitors of NO production are reported to alleviate migraine pain. We describe how constriction of larger upstream arteries, induced by NO synthesis inhibitors, may result in a compensatory dilatory response of the microvasculature. The restoration of central capillary blood flow may be the primary mechanism for pain relief. Attenuating the propensity for central capillary constriction and promoting a more dilatory phenotype may reduce frequency and severity of migraines. Here, we propose consideration of two dietary nutraceuticals for reducing migraine risk: L-arginine and aged garlic extracts.

Details

Title: A paradoxical vasodilatory nutraceutical intervention for prevention and attenuation of migraine—A hypothetical review
Authors/Creators: D.R. Chaliha (Author/Creator) - Curtin University
M. Vaccarezza (Author/Creator) - Curtin University
R. Takechi (Author/Creator) - Curtin University
V. Lam (Author/Creator) - Curtin University
E. Visser (Author/Creator) - The University of Notre Dame Australia
P. Drummond (Author/Creator) - Murdoch University
J.C.L. Mamo (Author/Creator) - Curtin University
Publication Details: Nutrients, Vol.12(8), Article 2487
Publisher: MDPI
Identifiers: 991005544481307891
Copyright: © 2020 by the authors
Murdoch Affiliation: School of Allied Health
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 3 Agriculture, Environment & Ecology; 3.16 Phytochemicals; 3.16.1953 Garlic and Onion Bioactives
Web Of Science research areas: Nutrition & Dietetics
ESI research areas: Agricultural Sciences