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Journal article
A personalised and comprehensive approach is required to suppress or replenish SNCA for Parkinson’s disease
NPJ Parkinson's Disease, Vol.11(1), 42
2025
Abstract
Based on the prevailing α-synuclein “gain-of-function” hypothesis, reducing α-synuclein levels and removing its aggregates is a current focus of disease-modifying therapies for Parkinson’s disease. Emerging evidence of α-synuclein “loss-of-function” suggests that it may be necessary to replenish monomeric α-synuclein levels. We propose a personalized and comprehensive approach for different Parkinson’s subgroups based on whether α-synuclein is likely to contribute to disease pathogenesis through a “gain-of-function”, “loss-of-function”, or both mechanisms.
Details
- Title
- A personalised and comprehensive approach is required to suppress or replenish SNCA for Parkinson’s disease
- Authors/Creators
- Dunhui Li - Murdoch University, Centre for Molecular Medicine and Innovative TherapeuticsWai Yan Yau - Perron Institute for Neurological and Translational ScienceShengdi Chen - Ruijin HospitalSteve Wilton - Murdoch University, Centre for Molecular Medicine and Innovative TherapeuticsFrank Mastaglia - Perron Institute for Neurological and Translational Science
- Publication Details
- NPJ Parkinson's Disease, Vol.11(1), 42
- Publisher
- Nature Publishing Group UK
- Number of pages
- 8
- Grant note
- Bryant Stokes Neurological Research FundChannel 7 Telethon Trust Research Fund
We would like to thank Professor Anthony E. Lang (Department of Medicine, Division of Neurology, University of Toronto) for his helpful review and constructive comments for this manuscript. Dr Li received salary support from the philanthropic Giumelli Family Foundation and receives research grants from Bryant Stokes Neurological Research Fund and Channel 7 Telethon Trust Research Fund. No other disclosures to report.
- Identifiers
- 991005750230207891
- Copyright
- © The Author(s) 2025
- Murdoch Affiliation
- Personalised Medicine Centre; Centre for Molecular Medicine and Innovative Therapeutics
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.67 Parkinson's Disease
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior