Journal article
A prospective controlled multicentre study of clarithromycin in pregnancy
American Journal of Perinatology, Vol.15(9), pp.523-525
1998
Abstract
Clarithromycin is a relatively new macrolide antibiotic with an action spectrum similar to that of erythromycin. Its main indications for use are for upper and lower respiratory and skin and soft tissue infections. Little is known about its safety in pregnancy, although animal reproductive studies found an increased rate of cardiovascular anomalies, cleft palate, and embryonic loss. Human data, limited to case reports and one small uncontrolled study, cannot allow evidence based counseling of pregnant women who were exposed to the drug before finding out they were pregnant. Pregnant women who had been counseled on the use of clarithromycin by five centers, were matched for age, smoking, and alcohol use with a control group of pregnant women who were exposed to nonteratogenic antibiotics. A total of 157 women were followed up. Of these, 122 were exposed to the drug in the first trimester. There were no significant differences found between the two groups in the rates of major and minor malformations; 2.3 versus 1.4% for major (p = 0.86) and 5.4 versus 4.9% for minor (p = 0.96). Spontaneous abortion rates in the exposed group was significantly different, higher (14%) than in the control group (7%) (p = 0.04). This first prospective controlled study of exposure to clarithromycin in pregnancy suggests that this agent does not increase the rate of major malformations above the baseline risk of 1-3%. The higher rate of reported spontaneous abortions, although still within the expected baseline rate, may warrant further study.
Details
- Title
- A prospective controlled multicentre study of clarithromycin in pregnancy
- Authors/Creators
- A. Einarson (Author/Creator)E. Phillips (Author/Creator)F. Mawji (Author/Creator)D. D'Alimonte (Author/Creator)B. Schick (Author/Creator)A. Addis (Author/Creator)P. Mastroiacova (Author/Creator)T. Mazzone (Author/Creator)D. Matsui (Author/Creator)G. Koren (Author/Creator)
- Publication Details
- American Journal of Perinatology, Vol.15(9), pp.523-525
- Publisher
- Thieme
- Identifiers
- 991005540476207891
- Copyright
- © 1998 by Thieme Medical Publishers, Inc.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
72 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Citation topics
- 1 Clinical & Life Sciences
- 1.72 Obstetrics & Gynecology
- 1.72.1745 Pregnancy Medication Safety
- Web Of Science research areas
- Obstetrics & Gynecology
- Pediatrics
- ESI research areas
- Clinical Medicine