A pseudo-three-dimensional model for quantification of oxygen diffusion from pre-glomerular arteries to renal tissue and renal venous blood

C-J Lee; J.P. Ngo; S. Kar; B.S. Gardiner; R.G. Evans; D.W. Smith

doi:10.1152/ajprenal.00659.2016

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A pseudo-three-dimensional model for quantification of oxygen diffusion from pre-glomerular arteries to renal tissue and renal venous blood

Journal article

Peer reviewed

A pseudo-three-dimensional model for quantification of oxygen diffusion from pre-glomerular arteries to renal tissue and renal venous blood

C-J Lee, J.P. Ngo, S. Kar, B.S. Gardiner, R.G. Evans and D.W. Smith

American Journal of Physiology - Renal Physiology, Vol.313(2), pp.F237-F253

2017

DOI: https://doi.org/10.1152/ajprenal.00659.2016

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Abstract

To assess the physiological significance of arterial-to-venous (AV) oxygen shunting, we generated a new pseudo-three-dimensional computational model of oxygen diffusion from intrarenal arteries to cortical tissue and veins. The model combines the eleven branching levels (known as 'Strahler' orders) of the pre-glomerular renal vasculature in the rat, with an analysis of an extensive dataset obtained using light microscopy to estimate oxygen mass transfer coefficients for each Strahler order. Further, the AV shunting model is now set within a global oxygen transport model that includes transport from arteries, glomeruli, peritubular capillaries and veins to tissue. While a number of lines of evidence suggest AV shunting is significant, most importantly our AV oxygen shunting model predicts AV shunting is small under normal physiological conditions (~0.9% of total renal oxygen delivery; range 0.4% to 1.4%), but increases during renal ischemia, glomerular hyperfiltration (~2.1% of total renal oxygen delivery; range 0.84% to 3.36%) and some cardiovascular disease states (~3.0% of total renal oxygen delivery; range 1.2% to 4.8%). Under normal physiological conditions, blood PO2 is predicted to fall by ~16 mmHg from the root of the renal artery to glomerular entry, with AV oxygen shunting contributing ~40% and oxygen diffusion from arteries to tissue contributing ~60% of this decline. Arterial PO2 is predicted to fall most rapidly from Strahler order 4, under normal physiological conditions. We conclude that AV oxygen shunting normally has only a small impact on renal oxygenation, but may exacerbate renal hypoxia during renal ischemia, hyperfiltration and some cardiovascular disease states.

Details

Title: A pseudo-three-dimensional model for quantification of oxygen diffusion from pre-glomerular arteries to renal tissue and renal venous blood
Authors/Creators: C-J Lee (Author/Creator) - The University of Western Australia
J.P. Ngo (Author/Creator) - Monash University
S. Kar (Author/Creator) - The University of Western Australia
B.S. Gardiner (Author/Creator) - Murdoch University
R.G. Evans (Author/Creator) - Monash University
D.W. Smith (Author/Creator) - The University of Western Australia
Publication Details: American Journal of Physiology - Renal Physiology, Vol.313(2), pp.F237-F253
Publisher: American Physiological Society
Identifiers: 991005541024007891
Copyright: © 2016, American Journal of Physiology-Renal Physiology
Murdoch Affiliation: School of Engineering and Information Technology
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.55 Urology & Nephrology - General; 1.55.830 Acute Kidney Injury
Web Of Science research areas: Physiology; Urology & Nephrology
ESI research areas: Clinical Medicine