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A randomised controlled trial comparing autologous cranioplasty with custom-made titanium cranioplasty: long-term follow-up
Journal article   Peer reviewed

A randomised controlled trial comparing autologous cranioplasty with custom-made titanium cranioplasty: long-term follow-up

S. Honeybul, D.A. Morrison, K.M. Ho, C.R.P. Lind and E. Geelhoed
Acta Neurochirurgica, Vol.160(5), pp.885-891
2018
DOI: https://doi.org/10.1007/s00701-018-3514-z
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Abstract

Objective To compare the long-term outcomes of patients who had been randomly allocated to receive primary titanium cranioplasty or autologous bone graft following decompressive craniectomy. Methods Sixty-four patients had been previously enrolled and randomised to receive either their own bone graft or a primary titanium cranioplasty. Functional and cosmetic outcomes had previously been assessed at 1-year following the cranioplasty procedure. Hospital records and the Picture Archiving communication system were reviewed to determine how many patients had cranioplasty failure or associated complications such as seizures beyond 1 year—with a minimum of 24-month follow-up. Results Amongst the 31 patients in the titanium group (one patient had died), no patients had a partial or complete cranioplasty failure at 12 months follow-up and there had been no failures beyond 12 months. Amongst the 31 patients who had an autologous cranioplasty (one patient had died), 7 patients had complete resorption of the autologous bone such that it was adjudged a complete failure at 12-month follow-up. Five of these patients had had titanium augmentation and two patients declined further surgery. Both of these patients requested cranial augmentation for functional and cosmetic reasons subsequent to the 12-month follow-up. Another patient who had previously been noted to have moderate resorption at 12 months presented 1 year later with progressive bone flap resorption and also required subsequent augmentation for functional and cosmetic reasons. When follow-up was extended to a minimum of 24 months, use of titanium instead of autologous bone for primary cranioplasty resulted in a significant reduction in the number of patients who required rescue cranioplasty (0 vs 25%, 95% confidence interval [CI] 9.1–42.1%; p = 0.001). In addition, there were significantly less total hospital healthcare costs in those patients randomised to the titanium arm of the trial (difference = A$9999, 95%CI 2231–17,768; p = 0.015). Conclusions Bone resorption continued to occur beyond 12 months after autologous cranioplasty; use of primary titanium cranioplasty after decompressive craniectomy reduced the number of reoperations needed and the associated long-term total hospital costs.

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Collaboration types
Domestic collaboration
Citation topics
1 Clinical & Life Sciences
1.173 Cosmetic Surgery
1.173.2783 Cranioplasty
Web Of Science research areas
Clinical Neurology
Surgery
ESI research areas
Clinical Medicine
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