A retrospective multi‐center study of treatment, outcome, and prognostic factors in 34 dogs with disseminated aspergillosis in Australia

Y.Y. Lim; C.S. Mansfield; M. Stevenson; M. Thompson; D. Davies; J. Whitney; F. James; A. Tebb; D. Fry; S. Buob; L. Hambrook; G. Boo; J.R.S. Dandrieux

doi:10.1111/jvim.16366

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A retrospective multi‐center study of treatment, outcome, and prognostic factors in 34 dogs with disseminated aspergillosis in Australia

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A retrospective multi‐center study of treatment, outcome, and prognostic factors in 34 dogs with disseminated aspergillosis in Australia

Y.Y. Lim, C.S. Mansfield, M. Stevenson, M. Thompson, D. Davies, J. Whitney, F. James, A. Tebb, D. Fry, S. Buob, …

Journal of Veterinary Internal Medicine, Vol.36(2), pp.580-590

2022

DOI: https://doi.org/10.1111/jvim.16366

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Abstract

Background Disseminated aspergillosis (DA) in dogs has a guarded prognosis and there is a lack of a gold standard treatment protocol. Objective To retrospectively assess survival times and factors influencing survival times. Animals Dogs diagnosed with DA from January 2007 to June 2017. Methods Disseminated aspergillosis case data were retrieved from 13 Australian veterinary referral centers, with a diagnosis confirmed with culture or PCR. Factors influencing survival time after diagnosis were quantified using a Cox proportional hazards regression model. Results Thirty-four dogs met the study inclusion criteria. Twenty-two dogs were treated with antifungal treatment and 12 dogs received no antifungal treatment. Accounting for censoring of dogs that were either still alive on the date of data collection or were loss to follow-up, dogs treated with itraconazole alone (n = 8) had a median survival time (MST) of 63 (95% CI: 20−272) days compared to 830 (95% CI: 267-1259) days for the n = 14 dogs that received multimodal antifungal therapy (

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Title: A retrospective multi‐center study of treatment, outcome, and prognostic factors in 34 dogs with disseminated aspergillosis in Australia
Authors/Creators: Y.Y. Lim (Author/Creator) - The University of Melbourne
C.S. Mansfield (Author/Creator) - The University of Melbourne
M. Stevenson (Author/Creator) - The University of Melbourne
M. Thompson (Author/Creator) - Murdoch University
D. Davies (Author/Creator) - Adelaide Veterinary Specialist & Referral Centre, Adelaide, South Australia, Australia.
J. Whitney (Author/Creator) - The University of Sydney
F. James (Author/Creator) - Western Australian Museum
A. Tebb (Author/Creator) - Government of Western Australia
D. Fry (Author/Creator) - Brisbane Veterinary Specialist Centre, Brisbane, Queensland, Australia.
S. Buob (Author/Creator) - Queensland Veterinary Specialists, Brisbane, Queensland, Australia.
L. Hambrook (Author/Creator) - Vetcare (Finland)
G. Boo (Author/Creator) - Eye Clinic for Animals, Sydney, New South Wales, Australia.
J.R.S. Dandrieux (Author/Creator) - The University of Melbourne
Publication Details: Journal of Veterinary Internal Medicine, Vol.36(2), pp.580-590
Publisher: American College of Veterinary Internal Medicine
Identifiers: 991005543098407891
Copyright: © 2022 The Authors.
Murdoch Affiliation: School of Veterinary Medicine
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.148 Medical Mycology; 1.148.94 Antifungal Strategies
Web Of Science research areas: Veterinary Sciences
ESI research areas: Plant & Animal Science