A retrospective study about association of dynamic systemic immune-inflammation index (SII) with 180-day functional outcome after basal ganglia intracerebral hemorrhage

Zhang Liang; He Liu; Li Xue; Bin Ma; Ling-Zhi Yang; Qing-Le Liang; Zhang-Ming Zhou

doi:10.1016/j.heliyon.2023.e16937

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A retrospective study about association of dynamic systemic immune-inflammation index (SII) with 180-day functional outcome after basal ganglia intracerebral hemorrhage

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A retrospective study about association of dynamic systemic immune-inflammation index (SII) with 180-day functional outcome after basal ganglia intracerebral hemorrhage

Zhang Liang, He Liu, Li Xue, Bin Ma, Ling-Zhi Yang, Qing-Le Liang and Zhang-Ming Zhou

Heliyon, Vol.9(6), e16937

2023

DOI: https://doi.org/10.1016/j.heliyon.2023.e16937

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Abstract

Basal ganglia intracerebral hemorrhage (ICH)

Biomarkers

Inflammation

Prognostic marker

Systemic immune-inflammation index (SII)

This study aimed to determine whether SII on different days of admission is associated with severity and 180-day functional outcomes after basal ganglia ICH. In this retrospective study, data on baseline CT imaging characteristics, mRS, hematoma volume, and laboratory variables were included. The SII and NLR, LMR, and PLR were calculated from laboratory data collected on admission day, day 1, and days 5–7. Both univariate and multivariable logistic regression analyses were used to assess the association between the SII and the outcome. The receiver operating characteristic (ROC) analysis and area under the curve (AUC) were also used to evaluate the ability of the SII to predict outcomes. A total of 245 patients were enrolled in the study. On different days, the NLR, PLR, and SII were significantly lower in patients with favorable outcomes than in those with poor outcomes, and the volume of hemorrhage was positively correlated with the SII. These parameters were associated with outcomes in the univariate logistic regression. In the adjusted analyses, the SII and PLR were independent predictors of basal ganglia ICH outcomes. ROC analysis revealed that the SII showed a stronger ability to predict the 6-month outcomes of patients after basal ganglia ICH than the PLR on different days (AUC = 0.642, 0.804, 0.827 vs. 0.592, 0.725, 0.757; all P < 0.001). The SII independently and strongly predicts the outcome of basal ganglia ICH. A high SII was associated with poor 6-month outcomes in patients with basal ganglia ICH.

Details

Title: A retrospective study about association of dynamic systemic immune-inflammation index (SII) with 180-day functional outcome after basal ganglia intracerebral hemorrhage
Authors/Creators: Zhang Liang - Department of Neurosurgery, Dujiangyan Medical Center, Chengdu, China
He Liu - Army Medical University
Li Xue - Southwest Jiaotong University
Bin Ma - Human Anatomy, College of Science, Health, Engineering and Education, Murdoch University, Perth, Australia
Ling-Zhi Yang - Chengdu Medical College
Qing-Le Liang - Jiangjin Central Hospital
Zhang-Ming Zhou - Department of Neurosurgery, Dujiangyan Medical Center, Chengdu, China
Publication Details: Heliyon, Vol.9(6), e16937
Publisher: Elsevier Ltd
Identifiers: 991005585964607891
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.105 Strokes; 1.105.142 Stroke Management
Web Of Science research areas: Clinical Neurology
ESI research areas: Neuroscience & Behavior