Journal article
A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium
The Lancet Infectious Diseases, Vol.15(1), pp.85-94
2015
Abstract
Cryptosporidium spp are well recognised as causes of diarrhoeal disease during waterborne epidemics and in immunocompromised hosts. Studies have also drawn attention to an underestimated global burden and suggest major gaps in optimum diagnosis, treatment, and immunisation. Cryptosporidiosis is increasingly identified as an important cause of morbidity and mortality worldwide. Studies in low-resource settings and high-income countries have confirmed the importance of cryptosporidium as a cause of diarrhoea and childhood malnutrition. Diagnostic tests for cryptosporidium infection are suboptimum, necessitating specialised tests that are often insensitive. Antigen-detection and PCR improve sensitivity, and multiplexed antigen detection and molecular assays are underused. Therapy has some effect in healthy hosts and no proven efficacy in patients with AIDS. Use of cryptosporidium genomes has helped to identify promising therapeutic targets, and drugs are in development, but methods to assess the efficacy in vitro and in animals are not well standardised. Partial immunity after exposure suggests the potential for successful vaccines, and several are in development; however, surrogates of protection are not well defined. Improved methods for propagation and genetic manipulation of the organism would be significant advances.
Details
- Title
- A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium
- Authors/Creators
- W. Checkley (Author/Creator) - Fogarty International CenterA.C. White (Author/Creator) - The University of Texas Medical Branch at GalvestonD. Jaganath (Author/Creator) - Johns Hopkins UniversityM.J. Arrowood (Author/Creator) - Centers for Disease Control and PreventionR.M. Chalmers (Author/Creator) - Public Health WalesX-M Chen (Author/Creator) - Creighton UniversityR. Fayer (Author/Creator) - Agricultural Research ServiceJ.K. Griffiths (Author/Creator) - Tufts UniversityR.L. Guerrant (Author/Creator) - University of VirginiaL. Hedstrom (Author/Creator) - Brandeis UniversityC.D. Huston (Author/Creator) - University of VermontK.L. Kotloff (Author/Creator) - University of Maryland, BaltimoreG. Kang (Author/Creator) - Christian Medical College, VelloreJ.R. Mead (Author/Creator) - Atlanta VA Medical CenterM. Miller (Author/Creator) - Fogarty International CenterW.A. Petri (Author/Creator) - University of VirginiaJ.W. Priest (Author/Creator) - Centers for Disease Control and PreventionD.S. Roos (Author/Creator) - University of PennsylvaniaB. Striepen (Author/Creator) - Center for Tropical and Emerging Global Diseases University of Georgia Athens GA USAR.C.A. Thompson (Author/Creator) - Murdoch UniversityH.D. Ward (Author/Creator) - Tufts Medical CenterW.A. van Voorhis (Author/Creator) - University of WashingtonL. Xiao (Author/Creator) - Centers for Disease Control and PreventionG. Zhu (Author/Creator) - Texas A&M UniversityE.R. Houpt (Author/Creator) - University of Virginia
- Publication Details
- The Lancet Infectious Diseases, Vol.15(1), pp.85-94
- Publisher
- Elsevier Ltd
- Identifiers
- 991005540786107891
- Copyright
- © 2014 Elsevier Ltd.
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
69 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
Highly Cited Paper
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.246 Diarrheal Diseases
- 1.246.985 Cryptosporidium
- Web Of Science research areas
- Infectious Diseases
- ESI research areas
- Immunology