A review of the pharmacology and clinical application of alfaxalone in cats

Leon N. Warne; Thierry Beths; Ted Whittem; Jennifer E. Carter; Sebastien H. Bauquier

doi:10.1016/j.tvjl.2014.12.011

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A review of the pharmacology and clinical application of alfaxalone in cats

Journal article

Open access

Peer reviewed

A review of the pharmacology and clinical application of alfaxalone in cats

Leon N. Warne, Thierry Beths, Ted Whittem, Jennifer E. Carter and Sebastien H. Bauquier

The veterinary journal (1997), Vol.203(2), pp.141-148

2015

DOI: https://doi.org/10.1016/j.tvjl.2014.12.011

PMID: 25582797

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Abstract

Life Sciences & Biomedicine

Science & Technology

Veterinary Sciences

Alfaxalone-2-hydroxpropyl-beta-cyclodextrin (alfaxalone-HPCD) was first marketed for veterinary use in Australia in 2001 and has since progressively became available throughout the world, including the USA, where in 2012 Food and Drug Administration (FDA) registration was granted. Despite the growing body of published works and increasing global availability of alfaxalone-HPCD, the accumulating evidence for its use in cats has not been thoroughly reviewed. The purpose of this review is: (1) to detail the pharmacokinetic properties of alfaxalone-HPCD in cats; (2) to assess the pharmacodynamic properties of alfaxalone-HPCD, including its cardiovascular, respiratory, central nervous system, neuromuscular, hepatic, renal, haematological, blood-biochemical, analgesic and endocrine effects; and (3) to consider the clinical application of alfaxalone-HPCD for sedation, induction and maintenance of anaesthesia in cats. Based on the published literature, alfaxalone-HPCD provides a good alternative to the existing intravenous anaesthetic options for healthy cats. (C) 2014 The Authors. Published by Elsevier Ltd.

Details

Title: A review of the pharmacology and clinical application of alfaxalone in cats
Authors/Creators: Leon N. Warne - The University of Melbourne
Thierry Beths - The University of Melbourne
Ted Whittem - The University of Melbourne
Jennifer E. Carter - The University of Melbourne
Sebastien H. Bauquier - The University of Melbourne
Publication Details: The veterinary journal (1997), Vol.203(2), pp.141-148
Publisher: Elsevier Ltd.
Number of pages: 8
Grant note: Jurox
Identifiers: 991005618220907891
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Citation topics: 1 Clinical & Life Sciences; 1.43 Anesthesiology; 1.43.1642 Veterinary Anesthesia
Web Of Science research areas: Veterinary Sciences
ESI research areas: Plant & Animal Science