Journal article
A short, convergent synthesis of aristolindiquinone
Journal of the Chemical Society, Perkin Transactions 1, (1), pp.85-85
1991
Abstract
Aristolindiquinone, 2,5-dihydroxy-3,8-dimethyl-1,4-naphthoquinone 1, is synthesised by the regiochemical addition of 1-methoxy-1-trimethylsiloxypenta-1, 3-diene 2 to 5-bromo-2-methoxy-3methyl-1,4-benzoquinone 3. The regioisomer 2,8-dihydroxy-3,5-dimethyl-1,4-naphthoquinone 4 is prepared by reaction of the same diene 2 with 2-methoxy-3-methyl-1,4-benzoquinone 11. The former reaction readily provided sufficient quantities of aristolindiquinone 1 for biological evaluation for fertility regulation in rats, for which purpose it was found to be inactive.
Details
- Title
- A short, convergent synthesis of aristolindiquinone
- Authors/Creators
- M.E. Botha (Author/Creator)R.G.F. Giles (Author/Creator)S.C. Yorke (Author/Creator)
- Publication Details
- Journal of the Chemical Society, Perkin Transactions 1, (1), pp.85-85
- Publisher
- Chemical Society
- Identifiers
- 991005540023507891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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