Journal article
A six-metabolite panel as potential blood-based biomarkers for Parkinson’s disease
npj Parkinson's Disease, Vol.7(1), Art. 94
2021
Abstract
Characterisation and diagnosis of idiopathic Parkinson’s disease (iPD) is a current challenge that hampers both clinical assessment and clinical trial development with the potential inclusion of non-PD cases. Here, we used a targeted mass spectrometry approach to quantify 38 metabolites extracted from the serum of 231 individuals. This cohort is currently one of the largest metabolomic studies including iPD patients, drug-naïve iPD, healthy controls and patients with Alzheimer’s disease as a disease-specific control group. We identified six metabolites (3-hydroxykynurenine, aspartate, beta-alanine, homoserine, ornithine (Orn) and tyrosine) that are significantly altered between iPD patients and control participants. A multivariate model to predict iPD from controls had an area under the curve (AUC) of 0.905, with an accuracy of 86.2%. This panel of metabolites may serve as a potential prognostic or diagnostic assay for clinical trial prescreening, or for aiding in diagnosing pathological disease in the clinic.
Details
- Title
- A six-metabolite panel as potential blood-based biomarkers for Parkinson’s disease
- Authors/Creators
- S. Klatt (Author/Creator) - Florey Institute of Neuroscience and Mental HealthJ.D. Doecke (Author/Creator) - Cooperative Research Centre for Mental HealthA. Roberts (Author/Creator) - Emory UniversityB.A. Boughton (Author/Creator) - The University of MelbourneC.L. Masters (Author/Creator) - Cooperative Research Centre for Mental HealthM. Horne (Author/Creator) - Florey Institute of Neuroscience and Mental HealthB.R. Roberts (Author/Creator) - Emory University
- Publication Details
- npj Parkinson's Disease, Vol.7(1), Art. 94
- Publisher
- Nature Publishing Group
- Identifiers
- 991005542024507891
- Copyright
- © 2021 The Authors.
- Murdoch Affiliation
- Australian National Phenome Centre
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.67 Parkinson's Disease
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior