A subset of malignant mesothelioma tumors retain osteogenic potential

S.M. Lansley; B. Pedersen; C. Robinson; R.G. Searles; G. Sterrett; I. van Bruggen; R.A. Lake; S.E. Mutsaers; C.M. Prêle

doi:10.1038/srep36349

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A subset of malignant mesothelioma tumors retain osteogenic potential

Journal article

Open access

Peer reviewed

A subset of malignant mesothelioma tumors retain osteogenic potential

S.M. Lansley, B. Pedersen, C. Robinson, R.G. Searles, G. Sterrett, I. van Bruggen, R.A. Lake, S.E. Mutsaers and C.M. Prêle

Scientific Reports, Vol.6(1), Art. 36349

2016

DOI: https://doi.org/10.1038/srep36349

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Abstract

Malignant mesothelioma (MM) is an aggressive serosal tumor associated with asbestos exposure. We previously demonstrated that mesothelial cells differentiate into cells of different mesenchymal lineages and hypothesize that osseous tissue observed in a subset of MM patients is due to local differentiation of MM cells. In this study, the capacity of human and mouse MM cells to differentiate into osteoblast-like cells was determined in vitro using a functional model of bone nodule formation and in vivo using an established model of MM. Human and murine MM cell lines cultured in osteogenic medium expressed alkaline phosphatase and formed mineralized bone-like nodules. Several human and mouse MM cell lines also expressed a number of osteoblast phenotype markers, including runt-related transcription factor 2 (RUNX2), osteopontin, osteonectin and bone sialoprotein mRNA and protein. Histological analysis of murine MM tumors identified areas of ossification within the tumor, similar to those observed in human MM biopsies. These data demonstrate the ability of MM to differentiate into another mesenchymal cell type and suggest that MM cells may contribute to the formation of the heterologous elements observed in MM tumors.

Details

Title: A subset of malignant mesothelioma tumors retain osteogenic potential
Authors/Creators: S.M. Lansley (Author/Creator) - School of Medicine and Pharmacology
B. Pedersen (Author/Creator) - School of Medicine and Pharmacology
C. Robinson (Author/Creator) - Harry Perkins Institute of Medical Research
R.G. Searles (Author/Creator) - School of Medicine and Pharmacology
G. Sterrett (Author/Creator) - School of Pathology and Laboratory Medicine
I. van Bruggen (Author/Creator) - School of Medicine and Pharmacology
R.A. Lake (Author/Creator) - School of Medicine and Pharmacology
S.E. Mutsaers (Author/Creator) - School of Medicine and Pharmacology
C.M. Prêle (Author/Creator) - School of Medicine and Pharmacology
Publication Details: Scientific Reports, Vol.6(1), Art. 36349
Publisher: Springer Nature
Identifiers: 991005544699907891
Copyright: © 2016 The Authors.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.297 Asbestos & Mesothelioma; 1.297.780 Asbestos-Mesothelioma Link
Web Of Science research areas: Oncology
ESI research areas: Clinical Medicine