Journal article
A systematic review of intervention studies examining nutritional and herbal therapies for mild cognitive impairment and dementia using neuroimaging methods: Study characteristics and intervention efficacy
Evidence-Based Complementary and Alternative Medicine, Vol.2017, pp.1-21
2017
Abstract
Neuroimaging facilitates the assessment of complementary medicines (CMs) by providing a noninvasive insight into their mechanisms of action in the human brain. This is important for identifying the potential treatment options for target disease cohorts with complex pathophysiologies. The aim of this systematic review was to evaluate study characteristics, intervention efficacy, and the structural and functional neuroimaging methods used in research assessing nutritional and herbal medicines for mild cognitive impairment (MCI) and dementia. Six databases were searched for articles reporting on CMs, dementia, and neuroimaging methods. Data were extracted from 21/2,742 eligible full text articles and risk of bias was assessed. Nine studies examined people with Alzheimer’s disease, 7 MCI, 4 vascular dementia, and 1 all-cause dementia. Ten studies tested herbal medicines, 8 vitamins and supplements, and 3 nootropics. Ten studies used electroencephalography (EEG), 5 structural magnetic resonance imaging (MRI), 2 functional MRI (fMRI), 3 cerebral blood flow (CBF), 1 single photon emission tomography (SPECT), and 1 positron emission tomography (PET). Four studies had a low risk of bias, with the majority consistently demonstrating inadequate reporting on randomisation, allocation concealment, blinding, and power calculations. A narrative synthesis approach was assumed due to heterogeneity in study methods, interventions, target cohorts, and quality. Eleven key recommendations are suggested to advance future work in this area.
Details
- Title
- A systematic review of intervention studies examining nutritional and herbal therapies for mild cognitive impairment and dementia using neuroimaging methods: Study characteristics and intervention efficacy
- Authors/Creators
- G.Z. Steiner (Author/Creator) - Western Sydney UniversityD.C. Mathersul (Author/Creator) - University of PennsylvaniaF. MacMillan (Author/Creator) - Western Sydney UniversityD.A. Camfield (Author/Creator) - Illawarra Health & Medical Research InstituteN.L. Klupp (Author/Creator) - Western Sydney UniversityS.W. Seto (Author/Creator) - Western Sydney UniversityY. Huang (Author/Creator) - Southern Medical UniversityM.I. Hohenberg (Author/Creator) - Camden and Campbelltown HospitalsD.H. Chang (Author/Creator) - Western Sydney University
- Publication Details
- Evidence-Based Complementary and Alternative Medicine, Vol.2017, pp.1-21
- Publisher
- Hindawi Publishing Corporation
- Identifiers
- 991005540097307891
- Copyright
- © 2017 Genevieve Z. Steiner et al.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.60 Dementia
- Web Of Science research areas
- Integrative & Complementary Medicine
- ESI research areas
- Clinical Medicine