Journal article
ALS genetics, mechanisms, and therapeutics: Where are we now?
Frontiers in Neuroscience, Vol.13
2019
Abstract
The scientific landscape surrounding amyotrophic lateral sclerosis (ALS) continues to shift as the number of genes associated with the disease risk and pathogenesis, and the cellular processes involved, continues to grow. Despite decades of intense research and over 50 potentially causative or disease-modifying genes identified, etiology remains unexplained and treatment options remain limited for the majority of ALS patients. Various factors have contributed to the slow progress in understanding and developing therapeutics for this disease. Here, we review the genetic basis of ALS, highlighting factors that have contributed to the elusiveness of genetic heritability. The most commonly mutated ALS-linked genes are reviewed with an emphasis on disease-causing mechanisms. The cellular processes involved in ALS pathogenesis are discussed, with evidence implicating their involvement in ALS summarized. Past and present therapeutic strategies and the benefits and limitations of the model systems available to ALS researchers are discussed with future directions for research that may lead to effective treatment strategies outlined.
Details
- Title
- ALS genetics, mechanisms, and therapeutics: Where are we now?
- Authors/Creators
- R. Mejzini (Author/Creator) - Murdoch UniversityL.L. Flynn (Author/Creator) - Murdoch UniversityI.L. Pitout (Author/Creator) - Murdoch UniversityS. Fletcher (Author/Creator) - Murdoch UniversityS.D. Wilton (Author/Creator) - Murdoch UniversityP.A. Akkari (Author/Creator) - Murdoch University
- Publication Details
- Frontiers in Neuroscience, Vol.13
- Publisher
- Frontiers
- Identifiers
- 991005543002407891
- Copyright
- © 2019 The Author(s)
- Murdoch Affiliation
- Centre for Molecular Medicine and Innovative Therapeutics
- Language
- English
- Resource Type
- Journal article
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Highly Cited Paper
- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.765 ALS Mechanisms
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior