Journal article
ATG16L1 gene polymorphisms are associated with palmoplantar pustulosis
Human Immunology, Vol.72(7), pp.613-615
2011
Abstract
Genes in autophagy pathway play an important role in innate and adaptive immunity. The aim of the study was to assess the impact of ATG16L1 gene on susceptibility of palmoplantar pustulosis. Four single nucleotide polymorphisms (SNPs) within the ATG16L1 region (rs2241880, rs2241879, rs7587633, and rs13005285) were genotyped in 241 control subjects and 38 palmoplantar pustulosis (PPP) patients of Estonian descent. The data analysis revealed a significantly higher frequency distribution of the rs2241880 G (odds ratio [OR] = 1.88, p = 0.0073) and rs2241879 A (OR = 1.87, p = 0.0079) allele in the PPP group when compared with the control group. The frequency distribution of the GACG haplotype was significantly higher (OR = 1.82, p = 0.016) in the PPP group when compared with the control group. The current study provides evidence of an association of the ATG16L1 gene in susceptibility to palmoplantar pustulosis, and supports the notion that the ATG16L1 gene as a member of the autophagy pathway most likely plays an important role in immune response.
Details
- Title
- ATG16L1 gene polymorphisms are associated with palmoplantar pustulosis
- Authors/Creators
- K. Douroudis (Author/Creator) - University of TartuK. Kingo (Author/Creator) - University of TartuT. Traks (Author/Creator) - University of TartuR. Rätsep (Author/Creator) - University of TartuH. Silm (Author/Creator) - University of TartuE. Vasar (Author/Creator) - University of TartuS. Kõks (Author/Creator) - University of Tartu
- Publication Details
- Human Immunology, Vol.72(7), pp.613-615
- Publisher
- Elsevier BV
- Identifiers
- 991005546002407891
- Copyright
- © 2011 American Society for Histocompatibility and Immunogenetics.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Citation topics
- 1 Clinical & Life Sciences
- 1.25 Molecular & Cell Biology - Cancer, Autophagy & Apoptosis
- 1.25.797 Autophagy
- Web Of Science research areas
- Immunology
- ESI research areas
- Immunology