Absence of a set of plasmid-encoded genes is predictive of reduced pathogenic potential in Brachyspira hyodysenteriae

T. La; N.D. Phillips; J.R. Thomson; D.J. Hampson

doi:10.1186/s13567-014-0131-6

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Absence of a set of plasmid-encoded genes is predictive of reduced pathogenic potential in Brachyspira hyodysenteriae

Journal article

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Absence of a set of plasmid-encoded genes is predictive of reduced pathogenic potential in Brachyspira hyodysenteriae

T. La, N.D. Phillips, J.R. Thomson and D.J. Hampson

Veterinary Research, Vol.45(1)

2014

DOI: https://doi.org/10.1186/s13567-014-0131-6

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Abstract

The gene content of 14 strains of the intestinal spirochaete Brachyspira hyodysenteriae was compared using a DNA microarray. A consistent difference occurred in a block of four genes on the ~36 Kb plasmid, with these being present in six virulent strains and absent in eight strains with reduced pathogenic potential. These genes encoded a predicted radical S-adenosylmethionine domain protein, a glycosyl transferase group 1-like protein, an NAD dependant epimerase and a dTDP-4-dehydrorhamnose 2–5 epimerase: they may be involved in rhamnose biosynthesis and glycosylation. The absence of these plasmid genes in B. hyodysenteriae isolates is predictive of reduced pathogenic potential.

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Title: Absence of a set of plasmid-encoded genes is predictive of reduced pathogenic potential in Brachyspira hyodysenteriae
Authors/Creators: T. La (Author/Creator) - Murdoch University
N.D. Phillips (Author/Creator) - Murdoch University
J.R. Thomson (Author/Creator) - Scottish Agricultural College
D.J. Hampson (Author/Creator) - Murdoch University
Publication Details: Veterinary Research, Vol.45(1)
Publisher: BioMed Central
Identifiers: 991005542557607891
Copyright: © 2014 La et al.
Murdoch Affiliation: School of Veterinary and Life Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.248 Sexually Transmitted Infections; 1.248.2445 Lawsonia Intracellularis
Web Of Science research areas: Veterinary Sciences
ESI research areas: Plant & Animal Science