Journal article
Active suppression rather than ignorance: Tolerance to abacavir-induced HLA-B*57:01 peptide repertoire alteration
Journal of Clinical Investigation, Vol.128(7), pp.2746-2749
2018
Abstract
The discovery of HLA-B*57:01–associated abacavir hypersensitivity is a translational success story that eliminated adverse reactions to abacavir through pretreatment screening and defined a mechanistic model of an altered peptide repertoire. In this issue of the JCI, Cardone et al. have developed an HLA-B*57:01–transgenic mouse model and demonstrated that CD4+ T cells play a key role in mediating tolerance to the dramatically altered endogenous peptide repertoire induced by abacavir and postulate a known mechanism by which CD4+ T cells suppress DC maturation. This report potentially explains why 45% of HLA-B*57:01 carriers tolerate abacavir and provides a framework for future studies of HLA-restricted, T cell–mediated drug tolerance and hypersensitivity.
Details
- Title
- Active suppression rather than ignorance: Tolerance to abacavir-induced HLA-B*57:01 peptide repertoire alteration
- Authors/Creators
- E.J. Phillips (Author/Creator)S.A. Mallal (Author/Creator)
- Publication Details
- Journal of Clinical Investigation, Vol.128(7), pp.2746-2749
- Publisher
- American Society for Clinical Investigation
- Identifiers
- 991005543579307891
- Copyright
- © 2018 American Society for Clinical Investigation
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
62 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.265 Dermatology - Skin Allergies
- 1.265.1140 Drug Hypersensitivity
- Web Of Science research areas
- Medicine, Research & Experimental
- ESI research areas
- Clinical Medicine