Journal article
Activity of oritavancin against methicillin-resistant staphylococci, vancomycin-resistant enterococci and -haemolytic streptococci collected from western European countries in 2011
Journal of Antimicrobial Chemotherapy, Vol.68(1), pp.164-167
2013
Abstract
Objectives
To determine the activity of oritavancin against methicillin-resistant staphylococci, vancomycin-resistant enterococci (VRE) and β-haemolytic streptococci recently isolated from acute bacterial skin and skin structure infections or bacteraemia in western Europe.
Methods
Forty-one centres in Spain (8), Italy (9), Germany (8), France (8) and the UK (8) submitted 866 isolates [204 methicillin-resistant Staphylococcus aureus (MRSA), 177 methicillin-resistant coagulase-negative staphylococci (MRCoNS), 101 VRE, 193 Streptococcus agalactiae and 191 Streptococcus pyogenes] that were collected during the first 6 months of 2011. These were re-identified and susceptibilities to oritavancin and comparators were determined.
Results
Oritavancin was very active against MRSA (MIC50/MIC90 0.03/0.06 mg/L), MRCoNS (0.06/0.12 mg/L), VRE (0.03/0.06 mg/L), S. agalactiae (0.03/0.06 mg/L) and S. pyogenes (0.06/0.25 mg/L). The highest oritavancin MIC observed was 0.25 mg/L (species were S. aureus, Staphylococcus epidermidis, Staphylococcus hominis, S. agalactiae, S. pyogenes and Enterococcus faecalis).
Conclusions
These data from recently collected Gram-positive bacteria in western Europe confirm the potent in vitro activity of oritavancin against a wide range of resistant MRSA, MRCoNS and VRE isolates, including ones resistant to newer agents.
Details
- Title
- Activity of oritavancin against methicillin-resistant staphylococci, vancomycin-resistant enterococci and -haemolytic streptococci collected from western European countries in 2011
- Authors/Creators
- I. Morrissey (Author/Creator)H. Seifert (Author/Creator)R. Canton (Author/Creator)P. Nordmann (Author/Creator)S. Stefani (Author/Creator)A. MacGowan (Author/Creator)R. Janes (Author/Creator)D. Knight (Author/Creator)
- Publication Details
- Journal of Antimicrobial Chemotherapy, Vol.68(1), pp.164-167
- Publisher
- Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy
- Identifiers
- 991005544141707891
- Copyright
- © The Author 2012
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.23 Antibiotics & Antimicrobials
- 1.23.173 MRSA and VRE
- Web Of Science research areas
- Infectious Diseases
- Microbiology
- Pharmacology & Pharmacy
- ESI research areas
- Pharmacology & Toxicology