Journal article
Adrenergic receptor responses of vascular smooth muscle in Becker dystrophy
Journal of the Neurological Sciences, Vol.46(3), pp.291-302
1980
Abstract
The effect of intravenous adrenaline and of alpha and beta blockade on muscle blood flow in the tibialis anterior muscle of 8 normal subjects and 8 patients with the Becker form of X-linked muscular dystrophy has been assessed using the 133Xe clearance method. Whereas beta receptor responses to stimulation by adrenaline and blocking by propranolol did not differ significantly in the Becker patients and normal controls, the degree of alpha receptor blockade produced by phentolamine was significantly less in the Becker patients, suggesting a quantitative or qualitative abnormality of vascular alpha receptors. This pattern of response was not found in patients with spinal muscular atrophy or polymyositis. The possible significance of these findings is considered.
Details
- Title
- Adrenergic receptor responses of vascular smooth muscle in Becker dystrophy
- Authors/Creators
- F. Mechler (Author/Creator) - Muscular Dystrophy Group Research Laboratories, Regional Neurological Centre, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE Great BritainF.L. Mastaglia (Author/Creator) - Muscular Dystrophy Group Research Laboratories, Regional Neurological Centre, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE Great BritainJ. Haggith (Author/Creator) - Department of Medical Physics, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE Great BritainD. Gardner-Medwin (Author/Creator) - Muscular Dystrophy Group Research Laboratories, Regional Neurological Centre, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE Great Britain
- Publication Details
- Journal of the Neurological Sciences, Vol.46(3), pp.291-302
- Publisher
- Elsevier BV
- Identifiers
- 991005544121607891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
29 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Citation topics
- 1 Clinical & Life Sciences
- 1.255 Musculoskeletal Disorders
- 1.255.628 Duchenne Muscular Dystrophy
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior