Journal article
Adrenergic receptors in the forehead microcirculation
Clinical Autonomic Research, Vol.6(1), pp.23-27
1996
Abstract
The presence of α- and β-adrenoceptors in the forehead microcirculation was investigated in 43 healthy subjects. Local vascular responses to noradrenaline, isoprenaline and adrenergic antagonists, administered transcutaneously by iontophoresis, were monitored via laser Doppler flowmetry. Iontophoresis of the α-adrenergic antagonist phentolamine induced a persistent increase in skin blood flow, whereas iontophoresis of saline induced a minor increase in skin blood flow which subsided rapidly. Skin blood flow increased moderately after the iontophoresis of the β-adrenergic antagonist propranolol. Pretreatment of the experimental site with phentolamine blocked the normal vasoconstrictor response to noradrenaline, and unmasked a minor vasodilator component of response in some subjects. Iontophoresis of the β-adrenergic agonist isoprenaline induced dose-dependent vasodilatation which was antagonised by propranolol. These findings indicate that α-adrenoceptors in the forehead microcirculation normally mediate a vasoconstrictor response to iontophoretically-applied noradrenaline. In addition, β-adrenoceptors appear to mediate a minor vasodilator component of response.
Details
- Title
- Adrenergic receptors in the forehead microcirculation
- Authors/Creators
- P.D. Drummond (Author/Creator) - Murdoch University
- Publication Details
- Clinical Autonomic Research, Vol.6(1), pp.23-27
- Publisher
- Springer
- Identifiers
- 991005543038307891
- Copyright
- Rapid Science Publishers
- Murdoch Affiliation
- School of Psychology
- Language
- English
- Resource Type
- Journal article
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